TY - JOUR
T1 - Oxidation of circulating proteins in alcoholics
T2 - Role of acetaldehyde and xanthine oxidase
AU - Grattagliano, Ignazio
AU - Vendemiale, Gianluigi
AU - Sabbà, Carlo
AU - Buonamico, Paolo
AU - Altomare, Emanuele
PY - 1996/7
Y1 - 1996/7
N2 - Background/Aims: This study aimed to evaluate the protein and lipid redox status in plasma, erythrocytes and erythrocyte ghosts of alcoholics and of patients with non-alcoholic liver disease; we also investigated the relation to glutathione levels and the role of acetaldehyde and xanthine oxidase activity in plasma. Methods: Carbonyl and sulfhydryl proteins, glutathione and malondialdehyde levels and the activity of the circulating xanthine oxidase were determined in: active and abstinent alcoholics, patients with chronic vital hepatitis and healthy controls. Results: Active alcoholics showed a decrease of sulfhydryl protein and glutathione concentrations in plasma, erythrocytes and ghosts compared to the other groups. Also, an increase of the carbonyl protein and malondialdehyde levels and of the activity of circulating xanthine oxidase (9.2±1.8 nmol · min · ml, p
AB - Background/Aims: This study aimed to evaluate the protein and lipid redox status in plasma, erythrocytes and erythrocyte ghosts of alcoholics and of patients with non-alcoholic liver disease; we also investigated the relation to glutathione levels and the role of acetaldehyde and xanthine oxidase activity in plasma. Methods: Carbonyl and sulfhydryl proteins, glutathione and malondialdehyde levels and the activity of the circulating xanthine oxidase were determined in: active and abstinent alcoholics, patients with chronic vital hepatitis and healthy controls. Results: Active alcoholics showed a decrease of sulfhydryl protein and glutathione concentrations in plasma, erythrocytes and ghosts compared to the other groups. Also, an increase of the carbonyl protein and malondialdehyde levels and of the activity of circulating xanthine oxidase (9.2±1.8 nmol · min · ml, p
KW - Acetaldehyde
KW - Alcoholic liver disease
KW - Carbonyl proteins
KW - Glutathione
KW - Sulfhydryl proteins
KW - Xanthine oxidase
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U2 - 10.1016/S0168-8278(96)80324-2
DO - 10.1016/S0168-8278(96)80324-2
M3 - Article
C2 - 8836898
AN - SCOPUS:0030198889
VL - 25
SP - 28
EP - 36
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 1
ER -