Oxidation of circulating proteins in alcoholics: Role of acetaldehyde and xanthine oxidase

Ignazio Grattagliano, Gianluigi Vendemiale, Carlo Sabbà, Paolo Buonamico, Emanuele Altomare

Research output: Contribution to journalArticle

Abstract

Background/Aims: This study aimed to evaluate the protein and lipid redox status in plasma, erythrocytes and erythrocyte ghosts of alcoholics and of patients with non-alcoholic liver disease; we also investigated the relation to glutathione levels and the role of acetaldehyde and xanthine oxidase activity in plasma. Methods: Carbonyl and sulfhydryl proteins, glutathione and malondialdehyde levels and the activity of the circulating xanthine oxidase were determined in: active and abstinent alcoholics, patients with chronic vital hepatitis and healthy controls. Results: Active alcoholics showed a decrease of sulfhydryl protein and glutathione concentrations in plasma, erythrocytes and ghosts compared to the other groups. Also, an increase of the carbonyl protein and malondialdehyde levels and of the activity of circulating xanthine oxidase (9.2±1.8 nmol · min · ml, p

Original languageEnglish
Pages (from-to)28-36
Number of pages9
JournalJournal of Hepatology
Volume25
Issue number1
DOIs
Publication statusPublished - Jul 1996

Keywords

  • Acetaldehyde
  • Alcoholic liver disease
  • Carbonyl proteins
  • Glutathione
  • Sulfhydryl proteins
  • Xanthine oxidase

ASJC Scopus subject areas

  • Gastroenterology

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