Oxidative and genotoxic damage after radio-iodine therapy of Graves' hyperthyroidism

M. Ballardin, R. Barsacchi, L. Bodei, N. Caraccio, R. Cristofani, F. Di Martino, M. Ferdeghini, C. Kusmic, G. Madeddu, F. Monzani, A. M. Rossi, I. Sbrana, A. Spanu, C. Traino, R. Barale

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate genetic damage and oxidative stress following a single therapeutic dose of 131I in Graves' disease patients monitored up to 180 days after treatment. Materials and methods: Genetic damage induction was estimated as the increase in micronuclei in peripheral lymphocytes of patients. As indicators of radiogenic oxidative stress, vitamin E and lipoperoxide levels were assessed in the plasma of patients, as well as the release of plasmic clastogenic factors measured by the induction of micronuclei in vitro in peripheral lymphocytes of a healthy donor. Results: Vitamin E depletion lasted at least 3 days and die basal level was restored within 7 days. No statistically significant variations were observed in lipoperoxide plasma levels. A sharp increase of micronuclei in the peripheral lymphocytes of patients was correlated (p131I on the genetic material, but also of oxidative stress, likely via the release of clastogenic factor.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalInternational Journal of Radiation Biology
Volume80
Issue number3
DOIs
Publication statusPublished - Mar 2004

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

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    Ballardin, M., Barsacchi, R., Bodei, L., Caraccio, N., Cristofani, R., Di Martino, F., Ferdeghini, M., Kusmic, C., Madeddu, G., Monzani, F., Rossi, A. M., Sbrana, I., Spanu, A., Traino, C., & Barale, R. (2004). Oxidative and genotoxic damage after radio-iodine therapy of Graves' hyperthyroidism. International Journal of Radiation Biology, 80(3), 209-216. https://doi.org/10.1080/0955300042000205555