Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia

Carlo Cervellati, Arianna Romani, Davide Seripa, Eleonora Cremonini, Cristina Bosi, Stefania Magon, Angelina Passaro, Carlo M. Bergamini, Alberto Pilotto, Giovanni Zuliani

Research output: Contribution to journalArticle

Abstract

This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral markers. Serum levels of hydroperoxides, homocysteine, advanced oxidation protein products, uric acid, thiols, and total and residual antioxidant power were assessed in 103 mild cognitive impairment (MCI), 89 LOAD, 54 VAD patients and 48 Controls. Compared with Controls, a similar oxidative unbalance (high hydroperoxides and low residual antioxidant power) was observed in MCI, LOAD and, although less pronounced, VAD. Moreover, individuals with simultaneously high levels of homocysteine and uric acid, both well-known risk factors for cardiovascular disease, had a high probability to be affected by VAD (O.R.:10.50; 95% C.I.: 2.33-47.2), but not LOAD (O.R.: 3.0; 95% C.I.:0.86-10.76) compared with individuals with normal values. Our data suggest that, although they might share a common OxS-related pathogenesis, VAD and LOAD might maintain some distinctive features, with a predominance of "vascular component" in VAD compared with LOAD.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalJournal of the Neurological Sciences
Volume337
Issue number1-2
DOIs
Publication statusPublished - Feb 15 2014

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Keywords

  • Dementia
  • Homocysteine
  • Late Onset Alzheimer's Disease
  • Oxidative stress
  • Uric acid
  • Vascular Dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Cervellati, C., Romani, A., Seripa, D., Cremonini, E., Bosi, C., Magon, S., Passaro, A., Bergamini, C. M., Pilotto, A., & Zuliani, G. (2014). Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia. Journal of the Neurological Sciences, 337(1-2), 156-161. https://doi.org/10.1016/j.jns.2013.11.041