Oxidative damage in human liver transplantation

Fiorella Biasi, Martino Bosco, Isabella Chiappino, Elena Chiarpotto, Giacomo Lanfranco, Antonio Ottobrelli, Graziella Massano, Pietro P. Donadio, Monica Vaj, Enzo Andorno, Mario Rizzetto, Mauro Salizzoni, Giuseppe Poli

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate oxygen-dependent hepatic reperfusion injury in humans following orthotopic liver transplantation. To this end, a number of blood indices of impaired tissue redox balance were monitored in 19 adult patients for 3 weeks after liver transplantation. Both red cell malonaldehyde and plasma lipid peroxides increased significantly soon after organ reperfusion. This finding was consistently accompanied by decreased plasma vitamin E and red cell total glutathione. A peak of oxidative stress, as measured by the parameters monitored, was evident within 24 h after reperfusion, together with a maximum expression of cytolysis, as measured by plasma alanine aminotransferase. The occurrence of redox imbalance after hepatic reperfusion was shown to be linearly related to irreversible cell damage. As regards the low plasma levels of the two antioxidants after reperfusion, only that of vitamin E appeared statistically related to oxidative stress. With the background of an increasing body of proof, mainly from animal models, the involvement of toxic oxygen metabolites in hepatic cytolysis following orthotopic liver transplantation appears likely. The statistical correlation among the markers of redox imbalance monitored indicates their combined use in further investigation.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalFree Radical Biology and Medicine
Volume19
Issue number3
DOIs
Publication statusPublished - 1995

Keywords

  • Antioxidants
  • Cytolysis
  • Free radicals
  • Lipid peroxidation
  • Liver transplantation
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)
  • Clinical Biochemistry
  • Medicine(all)
  • Toxicology

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