Oxidative imbalance in different neurodegenerative diseases with memory impairment

M. Gironi, A. Bianchi, A. Russo, M. Alberoni, L. Ceresa, A. Angelini, C. Cursano, E. Mariani, R. Nemni, C. Kullmann, E. Farina, F. Martinelli Boneschi

Research output: Contribution to journalArticle

Abstract

Background: Byproducts of oxidative metabolic reactions could play a role in the pathogenesis of several neurodegenerative diseases (ND) including Alzheimer's disease (AD). We designed a study aimed at investigating a large set of oxidative and antioxidant markers in a sample of patients affected by different forms of dementia or memory impairment. Methods: Serum levels of coenzyme Q10, malondialdehyde (MDA), the total, oxidized and reduced forms of glutathione (GStot, GSSG and GSH, respectively), reactive oxygen species, anti-oxidized low-density lipoprotein antibodies and antioxidant power (PAO) were investigated in patients affected by AD, mild cognitive impairment, dementia with Lewy bodies and Parkinson's disease with dementia. The patient sample (n = 66) was compared with healthy subjects (HC; n = 62), and a comparison across pathological subgroups was also performed. A multivariate logistic regression model was implemented in order to calculate an algorithm model for predicting the risk of developing a neurodegenerative disorder. Results: The comparison between the memory deficit (MD) group and HC showed a significant difference for MDA (MD: 6.3 ± 2.8 μg/l; HC: 9.1 ± 4.9 μg/l; p = 1.7 × 10-6), GStot (MD: 260.4 ± 62.6 mg/l; HC: 306.5 ± 60.7 mg/l; p = 2.2 × 10-5), GSH (MD: 208.9 ± 68.4 mg/l; HC: 295.3 ± 101.3 mg/l; p = 2.2 × 10 -7) and PAO (MD: 1,066.5 ± 247.7 μmol; HC: 954.9 ± 200.4 μmol; p = 0.8 × 10-3). By contrast, no differences in the levels of the studied markers were detected across the different forms of ND. An older age, higher levels of PAO, lower levels of GSH and MDA and the use of cardiovascular or antidepressant drugs were the most important factors associated with the carrier ship of neurodegenerative disorder. Conclusion: To our knowledge, this is the first study reporting similar oxidative imbalance in different forms of memory impairment, regardless of the specific etiology. Low GSH levels could be considered as a favorable factor in ND; at the same time it could be suggested that higher levels of PAO represent a counteracting mechanism against an increased oxidative stress. The association between vascular risk factors, depressive status and cognitive impairment is in line with findings in the literature.

Original languageEnglish
Pages (from-to)129-137
Number of pages9
JournalNeurodegenerative Diseases
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Memory Disorders
Neurodegenerative Diseases
Malondialdehyde
Dementia
coenzyme Q10
Alzheimer Disease
Antioxidants
Logistic Models
Cardiovascular Agents
Glutathione Disulfide
Ships
Antidepressive Agents
Glutathione
Parkinson Disease
Reactive Oxygen Species
Healthy Volunteers
Oxidative Stress
Antibodies
Serum
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Antioxidant
  • Mild cognitive impairment
  • Oxidative stress
  • Parkinson's disease
  • Vascular risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Gironi, M., Bianchi, A., Russo, A., Alberoni, M., Ceresa, L., Angelini, A., ... Martinelli Boneschi, F. (2011). Oxidative imbalance in different neurodegenerative diseases with memory impairment. Neurodegenerative Diseases, 8(3), 129-137. https://doi.org/10.1159/000319452

Oxidative imbalance in different neurodegenerative diseases with memory impairment. / Gironi, M.; Bianchi, A.; Russo, A.; Alberoni, M.; Ceresa, L.; Angelini, A.; Cursano, C.; Mariani, E.; Nemni, R.; Kullmann, C.; Farina, E.; Martinelli Boneschi, F.

In: Neurodegenerative Diseases, Vol. 8, No. 3, 03.2011, p. 129-137.

Research output: Contribution to journalArticle

Gironi, M, Bianchi, A, Russo, A, Alberoni, M, Ceresa, L, Angelini, A, Cursano, C, Mariani, E, Nemni, R, Kullmann, C, Farina, E & Martinelli Boneschi, F 2011, 'Oxidative imbalance in different neurodegenerative diseases with memory impairment', Neurodegenerative Diseases, vol. 8, no. 3, pp. 129-137. https://doi.org/10.1159/000319452
Gironi, M. ; Bianchi, A. ; Russo, A. ; Alberoni, M. ; Ceresa, L. ; Angelini, A. ; Cursano, C. ; Mariani, E. ; Nemni, R. ; Kullmann, C. ; Farina, E. ; Martinelli Boneschi, F. / Oxidative imbalance in different neurodegenerative diseases with memory impairment. In: Neurodegenerative Diseases. 2011 ; Vol. 8, No. 3. pp. 129-137.
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