Abstract
Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.
| Original language | English |
|---|---|
| Pages (from-to) | 262-269 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2006 |
Fingerprint
Keywords
- Alzheimer's disease
- Mild cognitive impairment
- Reactive oxygen species
- Total antioxidant capacity
- Total plasma homocysteine
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease. / Guidi, Ilaria; Galimberti, Daniela; Lonati, Silvia; Novembrino, Cristina; Bamonti, Fabrizia; Tiriticco, Marco; Fenoglio, Chiara; Venturelli, Eliana; Baron, Pierluigi; Bresolin, Nereo; Scarpini, Elio.
In: Neurobiology of Aging, Vol. 27, No. 2, 02.2006, p. 262-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease
AU - Guidi, Ilaria
AU - Galimberti, Daniela
AU - Lonati, Silvia
AU - Novembrino, Cristina
AU - Bamonti, Fabrizia
AU - Tiriticco, Marco
AU - Fenoglio, Chiara
AU - Venturelli, Eliana
AU - Baron, Pierluigi
AU - Bresolin, Nereo
AU - Scarpini, Elio
PY - 2006/2
Y1 - 2006/2
N2 - Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.
AB - Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.
KW - Alzheimer's disease
KW - Mild cognitive impairment
KW - Reactive oxygen species
KW - Total antioxidant capacity
KW - Total plasma homocysteine
UR - http://www.scopus.com/inward/record.url?scp=29844435497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29844435497&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2005.01.001
DO - 10.1016/j.neurobiolaging.2005.01.001
M3 - Article
C2 - 16399211
AN - SCOPUS:29844435497
VL - 27
SP - 262
EP - 269
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 2
ER -