Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease

Ilaria Guidi, Daniela Galimberti, Silvia Lonati, Cristina Novembrino, Fabrizia Bamonti, Marco Tiriticco, Chiara Fenoglio, Eliana Venturelli, Pierluigi Baron, Nereo Bresolin, Elio Scarpini

Research output: Contribution to journalArticlepeer-review


Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalNeurobiology of Aging
Issue number2
Publication statusPublished - Feb 2006


  • Alzheimer's disease
  • Mild cognitive impairment
  • Reactive oxygen species
  • Total antioxidant capacity
  • Total plasma homocysteine

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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