Oxidative modification of fibrinogen is associated with altered function and structure in the subacute phase of myocardial infarction

Matteo Becatti, Rossella Marcucci, Giulia Bruschi, Niccolò Taddei, Daniele Bani, Anna Maria Gori, Betti Giusti, Gian Franco Gensini, Rosanna Abbate, Claudia Fiorillo

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE - Among plasma proteins, fibrinogen represents a major target of oxidative modifications. In patients with post-acute myocardial infarction (6 months after the acute event), fibrinogen oxidation-induced carbonyls and fibrinogen function were estimated using in vitro and ex vivo approaches. Fibrinogen structural features and clot architecture were also explored. APPROACH AND RESULTS - In 39 patients with post-acute myocardial infarction and 28 age-, sex-, and risk factor-matched controls, oxidative stress markers (in plasma and in purified fibrinogen fractions), thrombin-catalyzed fibrin polymerization, and plasmin-induced fibrin lysis were estimated. Circular dichroism spectra of purified fibrinogen extracts, electron microscopy, and differential interference contrast microscopy analyses of fibrin clots were also performed. Marked signs of oxidative stress in plasma (P

Original languageEnglish
Pages (from-to)1355-1361
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume34
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • fibrinogen
  • myocardial infarction
  • oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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