TY - JOUR
T1 - Oxidative phosphorylation and F0F1 ATP synthase activity of human hepatocellular carcinoma
AU - Capuano, Ferdinando
AU - Varone, Davide
AU - D'Eri, Nicola
AU - Russo, Elisabetta
AU - Tommasi, Stefania
AU - Montemurro, Severine
AU - Prete, Ferdinande
AU - Papa, Sergio
PY - 1996
Y1 - 1996
N2 - A study of mitochondrial oxidative phosphorylation in biopsies from human hepatocellular carcinoma is presented. Tumour mitochondria as compared to control liver mitochondria, besides a reduced activity of complex IV (cytochrome c oxidase) of the respyratory chain, show a decreased phosphorylative capacity. This appears to be mainly related to a defective F0F1 ATP synthase complex, Use of an antibody against the F1 portion of the complex demonstrate a definite decrease for the β subunit of F1 in tumour mitochondria.
AB - A study of mitochondrial oxidative phosphorylation in biopsies from human hepatocellular carcinoma is presented. Tumour mitochondria as compared to control liver mitochondria, besides a reduced activity of complex IV (cytochrome c oxidase) of the respyratory chain, show a decreased phosphorylative capacity. This appears to be mainly related to a defective F0F1 ATP synthase complex, Use of an antibody against the F1 portion of the complex demonstrate a definite decrease for the β subunit of F1 in tumour mitochondria.
KW - FF ATP synthase
KW - Hepatocellular carcinoma
KW - Human tumour mitochondria
KW - Oxidative phosphorylation
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M3 - Article
C2 - 9132148
AN - SCOPUS:0029786667
VL - 38
SP - 1013
EP - 1022
JO - Biochemistry and Molecular Biology International
JF - Biochemistry and Molecular Biology International
SN - 1039-9712
IS - 5
ER -