Oxidative phosphorylation and F0F1 ATP synthase activity of human hepatocellular carcinoma

Ferdinando Capuano, Davide Varone, Nicola D'Eri, Elisabetta Russo, Stefania Tommasi, Severine Montemurro, Ferdinande Prete, Sergio Papa

Research output: Contribution to journalArticlepeer-review

Abstract

A study of mitochondrial oxidative phosphorylation in biopsies from human hepatocellular carcinoma is presented. Tumour mitochondria as compared to control liver mitochondria, besides a reduced activity of complex IV (cytochrome c oxidase) of the respyratory chain, show a decreased phosphorylative capacity. This appears to be mainly related to a defective F0F1 ATP synthase complex, Use of an antibody against the F1 portion of the complex demonstrate a definite decrease for the β subunit of F1 in tumour mitochondria.

Original languageEnglish
Pages (from-to)1013-1022
Number of pages10
JournalBiochemistry and Molecular Biology International
Volume38
Issue number5
Publication statusPublished - 1996

Keywords

  • FF ATP synthase
  • Hepatocellular carcinoma
  • Human tumour mitochondria
  • Oxidative phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

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