Oxidative stress after a carbohydrate meal contributes to the deterioration of diastolic cardiac function in nonhypertensive insulin-treated patients with moderately well controlled type 2 diabetes

H. Von Bibra, M. St. John Sutton, T. Schuster, A. Ceriello, T. Siegmund, P. M. Schumm-Draeger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The prevalence and prognostic importance of diastolic dysfunction in type 2 diabetes has only recently been appreciated. We tested the hypothesis that in insulin treated type 2 diabetes (D), carbohydrate consumption induces oxidative stress resulting in further impairment of diastolic function beyond structural myocardial stiffness. The effects of a pure carbohydrate breakfast (48 g) on oxidative stress and cardiac function were studied in the fasting and postmeal states in subjects without hypertension or overt cardiac disease (moderately well controlled D, n=21 and controls without D, n=20). Studied variables included systolic and early diastolic (E′) myocardial velocities, traditional metabolic and hemodynamic parameters, serum nitrotyrosine, and sVCAM-1. In D compared to control subjects, the postmeal increase () in glucose (1.44±2.78 vs. 0.11±0.72 mmol/l, p=0.04) and nitrotyrosine (0.34±0.37 vs. - 0.23±0.47 nM/l, p2 0.466) and for fasting E′ age, nitrotyrosine, and septal thickness (R2 0.400). In insulin requiring type 2 diabetes, carbohydrate consumption may induce oxidative stress that is associated with worsening diastolic function, indicating that this metabolic factor is an important determinant of diastolic dysfunction in the diabetic heart beyond the increase in structural myocardial stiffness.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalHormone and Metabolic Research
Volume45
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Oxidative stress
Medical problems
Type 2 Diabetes Mellitus
Meals
Deterioration
Oxidative Stress
Carbohydrates
Insulin
Fasting
Stiffness
Breakfast
Hemodynamics
Heart Diseases
Hypertension
Glucose
Serum
3-nitrotyrosine

Keywords

  • diastolic function
  • oxidative stress
  • postmeal hyperglycemia
  • tissue Doppler
  • type 2 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Oxidative stress after a carbohydrate meal contributes to the deterioration of diastolic cardiac function in nonhypertensive insulin-treated patients with moderately well controlled type 2 diabetes. / Von Bibra, H.; St. John Sutton, M.; Schuster, T.; Ceriello, A.; Siegmund, T.; Schumm-Draeger, P. M.

In: Hormone and Metabolic Research, Vol. 45, No. 6, 2013, p. 449-455.

Research output: Contribution to journalArticle

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