Abstract
The prevalence and prognostic importance of diastolic dysfunction in type 2 diabetes has only recently been appreciated. We tested the hypothesis that in insulin treated type 2 diabetes (D), carbohydrate consumption induces oxidative stress resulting in further impairment of diastolic function beyond structural myocardial stiffness. The effects of a pure carbohydrate breakfast (48 g) on oxidative stress and cardiac function were studied in the fasting and postmeal states in subjects without hypertension or overt cardiac disease (moderately well controlled D, n=21 and controls without D, n=20). Studied variables included systolic and early diastolic (E′) myocardial velocities, traditional metabolic and hemodynamic parameters, serum nitrotyrosine, and sVCAM-1. In D compared to control subjects, the postmeal increase () in glucose (1.44±2.78 vs. 0.11±0.72 mmol/l, p=0.04) and nitrotyrosine (0.34±0.37 vs. - 0.23±0.47 nM/l, p2 0.466) and for fasting E′ age, nitrotyrosine, and septal thickness (R2 0.400). In insulin requiring type 2 diabetes, carbohydrate consumption may induce oxidative stress that is associated with worsening diastolic function, indicating that this metabolic factor is an important determinant of diastolic dysfunction in the diabetic heart beyond the increase in structural myocardial stiffness.
| Original language | English |
|---|---|
| Pages (from-to) | 449-455 |
| Number of pages | 7 |
| Journal | Hormone and Metabolic Research |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- diastolic function
- oxidative stress
- postmeal hyperglycemia
- tissue Doppler
- type 2 diabetes
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
Cite this
Oxidative stress after a carbohydrate meal contributes to the deterioration of diastolic cardiac function in nonhypertensive insulin-treated patients with moderately well controlled type 2 diabetes. / Von Bibra, H.; St. John Sutton, M.; Schuster, T.; Ceriello, A.; Siegmund, T.; Schumm-Draeger, P. M.
In: Hormone and Metabolic Research, Vol. 45, No. 6, 2013, p. 449-455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxidative stress after a carbohydrate meal contributes to the deterioration of diastolic cardiac function in nonhypertensive insulin-treated patients with moderately well controlled type 2 diabetes
AU - Von Bibra, H.
AU - St. John Sutton, M.
AU - Schuster, T.
AU - Ceriello, A.
AU - Siegmund, T.
AU - Schumm-Draeger, P. M.
PY - 2013
Y1 - 2013
N2 - The prevalence and prognostic importance of diastolic dysfunction in type 2 diabetes has only recently been appreciated. We tested the hypothesis that in insulin treated type 2 diabetes (D), carbohydrate consumption induces oxidative stress resulting in further impairment of diastolic function beyond structural myocardial stiffness. The effects of a pure carbohydrate breakfast (48 g) on oxidative stress and cardiac function were studied in the fasting and postmeal states in subjects without hypertension or overt cardiac disease (moderately well controlled D, n=21 and controls without D, n=20). Studied variables included systolic and early diastolic (E′) myocardial velocities, traditional metabolic and hemodynamic parameters, serum nitrotyrosine, and sVCAM-1. In D compared to control subjects, the postmeal increase () in glucose (1.44±2.78 vs. 0.11±0.72 mmol/l, p=0.04) and nitrotyrosine (0.34±0.37 vs. - 0.23±0.47 nM/l, p2 0.466) and for fasting E′ age, nitrotyrosine, and septal thickness (R2 0.400). In insulin requiring type 2 diabetes, carbohydrate consumption may induce oxidative stress that is associated with worsening diastolic function, indicating that this metabolic factor is an important determinant of diastolic dysfunction in the diabetic heart beyond the increase in structural myocardial stiffness.
AB - The prevalence and prognostic importance of diastolic dysfunction in type 2 diabetes has only recently been appreciated. We tested the hypothesis that in insulin treated type 2 diabetes (D), carbohydrate consumption induces oxidative stress resulting in further impairment of diastolic function beyond structural myocardial stiffness. The effects of a pure carbohydrate breakfast (48 g) on oxidative stress and cardiac function were studied in the fasting and postmeal states in subjects without hypertension or overt cardiac disease (moderately well controlled D, n=21 and controls without D, n=20). Studied variables included systolic and early diastolic (E′) myocardial velocities, traditional metabolic and hemodynamic parameters, serum nitrotyrosine, and sVCAM-1. In D compared to control subjects, the postmeal increase () in glucose (1.44±2.78 vs. 0.11±0.72 mmol/l, p=0.04) and nitrotyrosine (0.34±0.37 vs. - 0.23±0.47 nM/l, p2 0.466) and for fasting E′ age, nitrotyrosine, and septal thickness (R2 0.400). In insulin requiring type 2 diabetes, carbohydrate consumption may induce oxidative stress that is associated with worsening diastolic function, indicating that this metabolic factor is an important determinant of diastolic dysfunction in the diabetic heart beyond the increase in structural myocardial stiffness.
KW - diastolic function
KW - oxidative stress
KW - postmeal hyperglycemia
KW - tissue Doppler
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84878537768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878537768&partnerID=8YFLogxK
U2 - 10.1055/s-0033-1333752
DO - 10.1055/s-0033-1333752
M3 - Article
C2 - 23426860
AN - SCOPUS:84878537768
VL - 45
SP - 449
EP - 455
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 6
ER -