Oxidative stress and a thrombophilic condition alcoholics without severe liver disease

R. Trotti, M. Carratelli, M. Barbieri, G. Micieli, D. Bosone, M. Rondanelli, P. Bo

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives. The degree of oxidative stress and its association with a thrombophilic condition, if any, were investigated in alcoholics before the onset of severe liver disease. Design and Methods. Reactive oxygen species and total antioxidant capacity were evaluated using two new kinetic spectrophotometric methods in a selected group of 45 consecutive chronic alcohol abusers and 42 apparently healthy moderate drinkers, used as controls. The hemostatic system was explored by detecting the plasma levels of prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin complexes (TAT) with enzyme-linked immunosorbent assays, while D-dimer plasma levels were measured with a turbidimetric immunoassay. Results. Reactive oxygen species were significantly higher (p

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalHaematologica
Volume86
Issue number1
Publication statusPublished - 2001

Keywords

  • Alcoholism
  • Oxidative stress
  • Thrombin generation

ASJC Scopus subject areas

  • Hematology

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