Oxidative stress and inflammation: Implications in uremia and hemodialysis

Carmelo Libetta, Vincenzo Sepe, Pasquale Esposito, Francesco Galli, Antonio Dal Canton

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative response and inflammation constitute a major defense against infections, but if not properly regulated they could also lead to a number of deleterious effects. Patients affected by different stages of acute and chronic kidney disease, particularly patients on hemodialysis, present a marked activation of oxidative and inflammatory processes. This condition exposes these patients to an elevated risk of morbidity and mortality. This Review is up to date and it analyses the newest notions about pathophysiological mechanisms of oxidative stress and inflammation in patients with renal diseases, also considering the different strategies studied to counterbalance this high risk state.

Original languageEnglish
Pages (from-to)1189-1198
Number of pages10
JournalClinical Biochemistry
Volume44
Issue number14-15
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Acute kidney injury
  • Chronic kidney disease
  • Hemodialysis
  • Oxidative stress
  • Reactive nitrogen species
  • Reactive oxygen species

ASJC Scopus subject areas

  • Clinical Biochemistry

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