TY - JOUR
T1 - Oxidative stress and inflammation
T2 - Implications in uremia and hemodialysis
AU - Libetta, Carmelo
AU - Sepe, Vincenzo
AU - Esposito, Pasquale
AU - Galli, Francesco
AU - Dal Canton, Antonio
PY - 2011/10
Y1 - 2011/10
N2 - Oxidative response and inflammation constitute a major defense against infections, but if not properly regulated they could also lead to a number of deleterious effects. Patients affected by different stages of acute and chronic kidney disease, particularly patients on hemodialysis, present a marked activation of oxidative and inflammatory processes. This condition exposes these patients to an elevated risk of morbidity and mortality. This Review is up to date and it analyses the newest notions about pathophysiological mechanisms of oxidative stress and inflammation in patients with renal diseases, also considering the different strategies studied to counterbalance this high risk state.
AB - Oxidative response and inflammation constitute a major defense against infections, but if not properly regulated they could also lead to a number of deleterious effects. Patients affected by different stages of acute and chronic kidney disease, particularly patients on hemodialysis, present a marked activation of oxidative and inflammatory processes. This condition exposes these patients to an elevated risk of morbidity and mortality. This Review is up to date and it analyses the newest notions about pathophysiological mechanisms of oxidative stress and inflammation in patients with renal diseases, also considering the different strategies studied to counterbalance this high risk state.
KW - Acute kidney injury
KW - Chronic kidney disease
KW - Hemodialysis
KW - Oxidative stress
KW - Reactive nitrogen species
KW - Reactive oxygen species
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U2 - 10.1016/j.clinbiochem.2011.06.988
DO - 10.1016/j.clinbiochem.2011.06.988
M3 - Article
C2 - 21777574
AN - SCOPUS:80052921322
VL - 44
SP - 1189
EP - 1198
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 14-15
ER -