Oxidative stress and lymphocytes in Alzheimer disease

P. Mecocci, A. Cherubini, M. C. Polidori, R. Cecchetti, F. Chionne, U. Senin

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress has been involved in the pahtogenesis of different neurodegenerative diseases. Recently high levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a sensitive marker of DNA damage, were found in both nuclear and mitochondrial DNA of the brain in Alzheimer disease (AD). In this study we measured 8-OHdG in lymphocyte DNA obtained from AD patients and from age-matched controls. The high levels of 8-OHdG found in the lymphocytes of AD patients support the hypothesis that a general imbalance is present in this disease between oxidants and antioxidants.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalArchives of Gerontology and Geriatrics
Volume26
Issue numberSUPPL.1
Publication statusPublished - 1998

Keywords

  • Alzheimer disease
  • DNA damage in lymphocytes
  • Oxidative stress

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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