TY - JOUR
T1 - Oxidative stress and neuroAIDS
T2 - Triggers, modulators and novel antioxidants
AU - Mollace, Vincenzo
AU - Nottet, Hans S L M
AU - Clayette, Pascal
AU - Turco, Maria C.
AU - Muscoli, Carolina
AU - Salvemini, Daniela
AU - Perno, Carlo F.
PY - 2001/7/1
Y1 - 2001/7/1
N2 - Neurological disorders represent one of the most common disturbances accompanying HIV infection. In the past few years, highly antiretroviral active therapy has significantly reduced the incidence of HIV-related diseases. However, neurological dysfunction in AIDS patients still remains an unresolved problem. Oxidative stress, which occurs in brain tissues of patients undergoing HIV infection and is implicated in cell death of both astroglia and neurones, has recently been suggested to play a role in the pathogenesis of neuroAIDS. Thus, a better understanding of the processes that trigger and modulate free radical formation in brain tissues of AIDS patients might help in a successful therapeutic approach to the neuropathogenesis of HIV infection.
AB - Neurological disorders represent one of the most common disturbances accompanying HIV infection. In the past few years, highly antiretroviral active therapy has significantly reduced the incidence of HIV-related diseases. However, neurological dysfunction in AIDS patients still remains an unresolved problem. Oxidative stress, which occurs in brain tissues of patients undergoing HIV infection and is implicated in cell death of both astroglia and neurones, has recently been suggested to play a role in the pathogenesis of neuroAIDS. Thus, a better understanding of the processes that trigger and modulate free radical formation in brain tissues of AIDS patients might help in a successful therapeutic approach to the neuropathogenesis of HIV infection.
UR - http://www.scopus.com/inward/record.url?scp=0035386540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035386540&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(00)01819-1
DO - 10.1016/S0166-2236(00)01819-1
M3 - Article
C2 - 11410272
AN - SCOPUS:0035386540
VL - 24
SP - 411
EP - 416
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 7
ER -