Oxidative stress and ventricular dysfunction in ischemic heart disease

Antonella Boraso, Claudio Ceconi, Anna Cargnoni, Palmira Bernocchi, Salvatore Curello, Roberto Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Ventricular dysfunction due to myocardial infarction is a result of a pathophysiological 'continuum', proceeding from a fully reversible alteration to the irreversible loss of myocardial tissue. Various studies have suggested that oxidative stress induced by acute ischemia may play a role for the progression of ventricular dysfunction to heart failure. Oxidative injury on the myocardium may be described as the result of two processes; a) a deficit of the endogenous anti-oxidant defence during ischemia, and b) a production of oxygen free radicals occurring during early reperfusion. Ventricular dysfunction may result from a direct action of oxygen free radicals on ion translocating proteins, particularly vulnerable to radical-induced oxidation at key sulfhydryl groups, and an indirect calcium-induced activation of proteases, leading to excitation-contraction uncoupling. A progressive increase in oxygen free radical injury and involvement of oxidative stress have been observed in the evolution of ventricular dysfunction, suggesting that oxidative stress may be an important determinant factor for prognosis. The specific role of oxidative stress in the progression of ischemia to failure is yet to be entirely defined; however, new therapeutic approaches may possibly influence the course of this progression by counteracting the oxidative injury.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalHeart Failure Reviews
Volume4
Issue number2
Publication statusPublished - 1999

Keywords

  • Ischemia
  • Oxidative stress
  • Reperfusion
  • Ventricular dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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