Oxidative stress biomarkers and chromogranin A in uremic patients: Effects of dialytic treatment

Giovanna Castoldi, Laura Antolini, Camila Bombardi, Lucia Perego, Paola Mariani, Maria Rosa Viganò, Giacomo Torti, Marco Casati, Angelo Corti, Gianpaolo Zerbini, Maria Grazia Valsecchi, Andrea Stella

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate oxidative stress in uremia and dialysis and chromogranin A, a stress hormone that could be related to oxidative processes. Methods: Plasma oxidative stress biomarkers (-SH, 8-OHdG, and ox-LDL) and chromogranin A were measured in 89 outpatients (21 uremic patients, 17 in peritoneal dialysis, and 51 in haemodialysis), and in 18 subjects with normal renal function. Results: -SH groups were significantly reduced in heamodialysis, peritoneal, and uremic patients as compared with the control group (p=0.01), while 8-OHdG was increased (p

Original languageEnglish
Pages (from-to)1387-1392
Number of pages6
JournalClinical Biochemistry
Volume43
Issue number18
DOIs
Publication statusPublished - Dec 2010

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Keywords

  • Chromogranin A
  • Dialysis
  • Oxidative stress biomarkers
  • Uremia

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Castoldi, G., Antolini, L., Bombardi, C., Perego, L., Mariani, P., Viganò, M. R., Torti, G., Casati, M., Corti, A., Zerbini, G., Valsecchi, M. G., & Stella, A. (2010). Oxidative stress biomarkers and chromogranin A in uremic patients: Effects of dialytic treatment. Clinical Biochemistry, 43(18), 1387-1392. https://doi.org/10.1016/j.clinbiochem.2010.08.028