Abstract
The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression. Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death and have been associated with cancer suppression. Thus, it is crucial to consider the double-face of ROS, for novel therapeutic strategies targeting redox regulatory mechanisms. In this review, in order to derive cancer-type specific oxidative stress genes' profile and their potential prognostic role, we integrated a publicly available oxidative stress gene signature with patient survival data from the Cancer Genome Atlas database. Overall, we found several genes statistically significant associated with poor prognosis in the examined six tumor types. Among them, FoxM1 and thioredoxin reductase1 expression showed the same pattern in four out of six cancers, suggesting their specific critical role in cancer-related oxidative stress adaptation. Our analysis also unveiled an enriched cellular network, highlighting specific pathways, in which many genes are strictly correlated. Finally, we discussed novel findings on the correlation between oxidative stress and cancer stem cells in order to define those pathways to be prioritized in drug development.
| Original language | English |
|---|---|
| Article number | 2597581 |
| Journal | Oxidative Medicine and Cellular Longevity |
| Volume | 2017 |
| DOIs | |
| Publication status | Published - 2017 |
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ASJC Scopus subject areas
- Biochemistry
- Ageing
- Cell Biology
Cite this
Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis : Identification of Crucial Pathways Might Select Novel Therapeutic Approaches. / Leone, Alessandra; Roca, Maria Serena; Ciardiello, Chiara; Costantini, Susan; Budillon, Alfredo.
In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 2597581, 2017.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis
T2 - Identification of Crucial Pathways Might Select Novel Therapeutic Approaches
AU - Leone, Alessandra
AU - Roca, Maria Serena
AU - Ciardiello, Chiara
AU - Costantini, Susan
AU - Budillon, Alfredo
PY - 2017
Y1 - 2017
N2 - The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression. Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death and have been associated with cancer suppression. Thus, it is crucial to consider the double-face of ROS, for novel therapeutic strategies targeting redox regulatory mechanisms. In this review, in order to derive cancer-type specific oxidative stress genes' profile and their potential prognostic role, we integrated a publicly available oxidative stress gene signature with patient survival data from the Cancer Genome Atlas database. Overall, we found several genes statistically significant associated with poor prognosis in the examined six tumor types. Among them, FoxM1 and thioredoxin reductase1 expression showed the same pattern in four out of six cancers, suggesting their specific critical role in cancer-related oxidative stress adaptation. Our analysis also unveiled an enriched cellular network, highlighting specific pathways, in which many genes are strictly correlated. Finally, we discussed novel findings on the correlation between oxidative stress and cancer stem cells in order to define those pathways to be prioritized in drug development.
AB - The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression. Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death and have been associated with cancer suppression. Thus, it is crucial to consider the double-face of ROS, for novel therapeutic strategies targeting redox regulatory mechanisms. In this review, in order to derive cancer-type specific oxidative stress genes' profile and their potential prognostic role, we integrated a publicly available oxidative stress gene signature with patient survival data from the Cancer Genome Atlas database. Overall, we found several genes statistically significant associated with poor prognosis in the examined six tumor types. Among them, FoxM1 and thioredoxin reductase1 expression showed the same pattern in four out of six cancers, suggesting their specific critical role in cancer-related oxidative stress adaptation. Our analysis also unveiled an enriched cellular network, highlighting specific pathways, in which many genes are strictly correlated. Finally, we discussed novel findings on the correlation between oxidative stress and cancer stem cells in order to define those pathways to be prioritized in drug development.
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UR - http://www.scopus.com/inward/citedby.url?scp=85026556313&partnerID=8YFLogxK
U2 - 10.1155/2017/2597581
DO - 10.1155/2017/2597581
M3 - Review article
AN - SCOPUS:85026556313
VL - 2017
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
SN - 1942-0900
M1 - 2597581
ER -