Abstract
Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level − namely oxidative stress, genomic instability and DNA damage and repair biomarkers −were revised and compared. A total of 25 studies fulfilled inclusion/exclusion criteria and, consequently, were included in the review. Variations of oxidative stress biomarkers were often associated to frailty status in older people. On the contrary, genomic instability seems not to be linked to frailty. The only study which addressed the possible relationship between DNA repair modulations and frailty status also failed in finding association. Despite the large number of cellular alterations known to be associated with frailty, studies on this issue are still very scarce and limited to some of the possible cellular targets. The established link between DNA repair, genomic instability, and age and age-related disorders, encourage deeper investigations on this line.
| Original language | English |
|---|---|
| Pages (from-to) | 1-15 |
| Number of pages | 15 |
| Journal | Ageing Research Reviews |
| Volume | 37 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Cellular biomarkers
- DNA repair
- Elderly
- Frailty
- Genomic instability
- Oxidative stress
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Ageing
- Molecular Biology
- Neurology
Cite this
Oxidative stress, genomic features and DNA repair in frail elderly : A systematic review. / Sánchez-Flores, María; Marcos-Pérez, Diego; Costa, Solange; Teixeira, João Paulo; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa.
In: Ageing Research Reviews, Vol. 37, 01.08.2017, p. 1-15.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Oxidative stress, genomic features and DNA repair in frail elderly
T2 - A systematic review
AU - Sánchez-Flores, María
AU - Marcos-Pérez, Diego
AU - Costa, Solange
AU - Teixeira, João Paulo
AU - Bonassi, Stefano
AU - Pásaro, Eduardo
AU - Laffon, Blanca
AU - Valdiglesias, Vanessa
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level − namely oxidative stress, genomic instability and DNA damage and repair biomarkers −were revised and compared. A total of 25 studies fulfilled inclusion/exclusion criteria and, consequently, were included in the review. Variations of oxidative stress biomarkers were often associated to frailty status in older people. On the contrary, genomic instability seems not to be linked to frailty. The only study which addressed the possible relationship between DNA repair modulations and frailty status also failed in finding association. Despite the large number of cellular alterations known to be associated with frailty, studies on this issue are still very scarce and limited to some of the possible cellular targets. The established link between DNA repair, genomic instability, and age and age-related disorders, encourage deeper investigations on this line.
AB - Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level − namely oxidative stress, genomic instability and DNA damage and repair biomarkers −were revised and compared. A total of 25 studies fulfilled inclusion/exclusion criteria and, consequently, were included in the review. Variations of oxidative stress biomarkers were often associated to frailty status in older people. On the contrary, genomic instability seems not to be linked to frailty. The only study which addressed the possible relationship between DNA repair modulations and frailty status also failed in finding association. Despite the large number of cellular alterations known to be associated with frailty, studies on this issue are still very scarce and limited to some of the possible cellular targets. The established link between DNA repair, genomic instability, and age and age-related disorders, encourage deeper investigations on this line.
KW - Cellular biomarkers
KW - DNA repair
KW - Elderly
KW - Frailty
KW - Genomic instability
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85019060951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019060951&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2017.05.001
DO - 10.1016/j.arr.2017.05.001
M3 - Review article
AN - SCOPUS:85019060951
VL - 37
SP - 1
EP - 15
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
ER -