Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

E. Mariani, M. C. Polidori, A. Cherubini, P. Mecocci

Research output: Contribution to journalArticlepeer-review

Abstract

According to the free radical theory, aging can be considered as a progressive, inevitable process partially related to the accumulation of oxidative damage into biomolecules - nucleic acids, lipids, proteins or carbohydrates - due to an imbalance between prooxidants and antioxidants in favor of the former. More recently also the pathogenesis of several diseases has been linked to a condition of oxidative stress. In this review we focus our attention on the evidence of oxidative stress in aging brain, some of the most important neurodegenerative diseases - Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) - and in two common and highly disabling vascular pathologies - stroke and cardiac failure. Particular attention will be given to the current knowledge about the biomarkers of oxidative stress that can be possibly used to monitor their severity and outcome.

Original languageEnglish
Pages (from-to)65-75
Number of pages11
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume827
Issue number1
DOIs
Publication statusPublished - Nov 15 2005

Keywords

  • Aging
  • Brain
  • Neurodegeneration
  • Oxidative stress
  • Vascular

ASJC Scopus subject areas

  • Biochemistry

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