TY - JOUR
T1 - Oxidative stress in the metabolic syndrome
AU - Esposito, K.
AU - Ciotola, M.
AU - Schisano, B.
AU - Misso, L.
AU - Giannetti, G.
AU - Ceriello, A.
AU - Giugliano, Dario
PY - 2006/10
Y1 - 2006/10
N2 - The metabolic syndrome represents a cluster of several risk factors for atherosclerosis that increases the risk of future cardiovascular events. In this study, we evaluated whether oxidative stress is increased in subjects with the metabolic syndrome. We studied 100 subjects (50 men and 50 women) with the metabolic syndrome, as defined by the Adult Treatment Panel III, and 50 (25 men and 25 women) matched subjects without the syndrome. Insulin sensitivity was assessed with the homeostasis model assessment (HOMA) methods; endothelium-dependent flow-mediated vasodilation (FMD) was evaluated in the right brachial artery with a high-resolution ultrasound machine; oxidative stress was assessed by measuring the circulating levels of nitrotyrosine (NT), considered a good marker for the formation of endogenous peroxynitrite. Compared with control subjects, patients with the metabolic syndrome had greater waist circumference, higher HOMA and systolic pressure values, higher triglyceride and lower HDL-cholesterol levels. NT levels were higher (0.44±0.12 μmol/l, mean±SD) while FMD was lower [7.3 (4.4/9.6), median and interquartile range] in subjects with the metabolic syndrome as compared with control subjects [0.27±0.08 and 11.8 (8.6/14.9), respectively, p
AB - The metabolic syndrome represents a cluster of several risk factors for atherosclerosis that increases the risk of future cardiovascular events. In this study, we evaluated whether oxidative stress is increased in subjects with the metabolic syndrome. We studied 100 subjects (50 men and 50 women) with the metabolic syndrome, as defined by the Adult Treatment Panel III, and 50 (25 men and 25 women) matched subjects without the syndrome. Insulin sensitivity was assessed with the homeostasis model assessment (HOMA) methods; endothelium-dependent flow-mediated vasodilation (FMD) was evaluated in the right brachial artery with a high-resolution ultrasound machine; oxidative stress was assessed by measuring the circulating levels of nitrotyrosine (NT), considered a good marker for the formation of endogenous peroxynitrite. Compared with control subjects, patients with the metabolic syndrome had greater waist circumference, higher HOMA and systolic pressure values, higher triglyceride and lower HDL-cholesterol levels. NT levels were higher (0.44±0.12 μmol/l, mean±SD) while FMD was lower [7.3 (4.4/9.6), median and interquartile range] in subjects with the metabolic syndrome as compared with control subjects [0.27±0.08 and 11.8 (8.6/14.9), respectively, p
KW - Endothelium-dependent vasodilation
KW - Insulin resistance
KW - Metabolic syndrome
KW - Nitrotyrosine
UR - http://www.scopus.com/inward/record.url?scp=33845305811&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845305811&partnerID=8YFLogxK
M3 - Article
C2 - 17114909
AN - SCOPUS:33845305811
VL - 29
SP - 791
EP - 795
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 9
ER -