Oxidative stress in the pathogenesis of systemic scleroderma: An overview

Rosa Vona, Antonello Giovannetti, Lucrezia Gambardella, Walter Malorni, Donatella Pietraforte, Elisabetta Straface

Research output: Contribution to journalReview articlepeer-review


Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability and death as the result of end-stage organ failure. Two clinical subsets of the SSc are accepted: limited cutaneous SSc (lc-SSc) and diffuse cutaneous SSc (dc-SSc). At present, the aetiology and pathogenesis of SSc remain obscure, and consequently, disease outcome is unpredictable. Numerous studies suggest that reactive oxidizing species (ROS) play an important role in the pathogenesis of scleroderma. Over the years, several reports have supported this hypothesis for both lc-SSc and dc-SSc, although the specific role of oxidative stress in the pathogenesis of vascular injury and fibrosis remains to be clarified. The aim of the present review was to report and comment the recent findings regarding the involvement and role of oxidative stress in SSc pathogenesis. Biomarkers proving the link between ROS and the main pathological features of SSc have been summarized.

Original languageEnglish
Pages (from-to)3308-3314
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Issue number7
Publication statusPublished - Jul 1 2018


  • antioxidants
  • biomarkers
  • gender differences
  • oxidative stress
  • Raynaud's phenomenon
  • reactive oxidizing species
  • scleroderma

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology


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