Oxidative stress-related increase in ubiquitination in early coronary atherogenesis.

Joerg Hermann, Rajiv Gulati, Claudio Napoli, Julie E. Woodrum, Lilach O. Lerman, Martin Rodriguez-Porcel, Vincenzo Sica, Robert D. Simari, Aaron Ciechanover, Amir Lerman

Research output: Contribution to journalArticlepeer-review


The ubiquitin-proteasome system (UPS) is involved in the removal of damaged proteins and the activation of transcription factors, such as nuclear-factor-kappaB. Recent reports, however, questioned the functional activity of the UPS under conditions of increased oxidative stress, such as experimental hypercholesterolemia, which was the objective of our study. Pigs were placed on a normal chow diet (N) or on a hypercholesterolemic diet without (HC) or with vitamin C and E supplementation (HC+VIT) for 12 weeks. Compared with N, plasma concentration of total cholesterol increased in both HC and HC+VIT [76 +/- 21 vs. 400 +/- 148 (P

Original languageEnglish
Pages (from-to)1730-1732
Number of pages3
JournalFASEB Journal
Issue number12
Publication statusPublished - 2003


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