Oxidized lipoproteins and endothelium

Angela Pirillo, Weimin Zhu, Giuseppe D. Norata, Tiziano Zanelli, Laura Barberi, Paola Roma, Alberico L. Catapano

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelium is an early target of pro-atherosclerotic events, which may result in functional and morphological perturbations. Oxidized low density lipoproteins, an atherogenic factor with strong cytotoxicity, may potentially contribute to altered endothelial function through the activation of a stress response, which would rescue cells to full vitality, or, conversely, by leading to cell death. Evidence is presented here for the ability of chemically oxidized low density lipoproteins to induce the synthesis of the inducible form of heat shock protein 70 in cultured human endothelial cells, and for the association of epitopes of these modified lipoproteins with apoptotic endothelial cells in aortic sections from hypercholesterolemic rabbits.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume38
Issue number2
Publication statusPublished - 2000

Keywords

  • Apoptosis
  • Endothelium
  • Hsp70
  • Oxidized LDL

ASJC Scopus subject areas

  • Clinical Biochemistry

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