Abstract
Endothelium is an early target of pro-atherosclerotic events, which may result in functional and morphological perturbations. Oxidized low density lipoproteins, an atherogenic factor with strong cytotoxicity, may potentially contribute to altered endothelial function through the activation of a stress response, which would rescue cells to full vitality, or, conversely, by leading to cell death. Evidence is presented here for the ability of chemically oxidized low density lipoproteins to induce the synthesis of the inducible form of heat shock protein 70 in cultured human endothelial cells, and for the association of epitopes of these modified lipoproteins with apoptotic endothelial cells in aortic sections from hypercholesterolemic rabbits.
| Original language | English |
|---|---|
| Pages (from-to) | 155-160 |
| Number of pages | 6 |
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 38 |
| Issue number | 2 |
| Publication status | Published - 2000 |
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Keywords
- Apoptosis
- Endothelium
- Hsp70
- Oxidized LDL
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Oxidized lipoproteins and endothelium. / Pirillo, Angela; Zhu, Weimin; Norata, Giuseppe D.; Zanelli, Tiziano; Barberi, Laura; Roma, Paola; Catapano, Alberico L.
In: Clinical Chemistry and Laboratory Medicine, Vol. 38, No. 2, 2000, p. 155-160.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxidized lipoproteins and endothelium
AU - Pirillo, Angela
AU - Zhu, Weimin
AU - Norata, Giuseppe D.
AU - Zanelli, Tiziano
AU - Barberi, Laura
AU - Roma, Paola
AU - Catapano, Alberico L.
PY - 2000
Y1 - 2000
N2 - Endothelium is an early target of pro-atherosclerotic events, which may result in functional and morphological perturbations. Oxidized low density lipoproteins, an atherogenic factor with strong cytotoxicity, may potentially contribute to altered endothelial function through the activation of a stress response, which would rescue cells to full vitality, or, conversely, by leading to cell death. Evidence is presented here for the ability of chemically oxidized low density lipoproteins to induce the synthesis of the inducible form of heat shock protein 70 in cultured human endothelial cells, and for the association of epitopes of these modified lipoproteins with apoptotic endothelial cells in aortic sections from hypercholesterolemic rabbits.
AB - Endothelium is an early target of pro-atherosclerotic events, which may result in functional and morphological perturbations. Oxidized low density lipoproteins, an atherogenic factor with strong cytotoxicity, may potentially contribute to altered endothelial function through the activation of a stress response, which would rescue cells to full vitality, or, conversely, by leading to cell death. Evidence is presented here for the ability of chemically oxidized low density lipoproteins to induce the synthesis of the inducible form of heat shock protein 70 in cultured human endothelial cells, and for the association of epitopes of these modified lipoproteins with apoptotic endothelial cells in aortic sections from hypercholesterolemic rabbits.
KW - Apoptosis
KW - Endothelium
KW - Hsp70
KW - Oxidized LDL
UR - http://www.scopus.com/inward/record.url?scp=0034096437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034096437&partnerID=8YFLogxK
M3 - Article
C2 - 10834403
AN - SCOPUS:0034096437
VL - 38
SP - 155
EP - 160
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 2
ER -