Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice

Mario Sansone, Claudio Castellano, Mario Battaglia, Martine Ammassari-Teule

Research output: Contribution to journalArticle

Abstract

The nicotinic antagonist mecamylamine (2.5 and 5 mg/kg/IP) depressed both active (shuttle-box) and passive (step-through) avoidance learning in mice of the DBA/2 strain. The nootropic drug oxiracetam (50 and 100 mg/kg/IP) improved acquisition in the multitrial active avoidance test, but had no effect on one-trial passive avoidance learning. When the two drugs were combined, oxiracetam did not counteract mecamylamine-induced impairment of passive avoidance learning, even if it maintained a facilitating action on shuttle-box avoidance acquisition in mice receiving the nicotinic receptor blocker. Prevention of mecamylamine-induced shuttle-box avoidance depression by oxiracetam indicates that central nicotinic mechanisms are probably involved in the improving effects exerted by nootropic drugs on learning.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number2
DOIs
Publication statusPublished - 1990

Fingerprint

Avoidance Learning
Mecamylamine
Nootropic Agents
Nicotinic Antagonists
Inbred DBA Mouse
Nicotinic Receptors
Learning
Depression
Pharmaceutical Preparations
oxiracetam

Keywords

  • Avoidance learning
  • Mecamylamine
  • Mice
  • Oxiracetam

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice. / Sansone, Mario; Castellano, Claudio; Battaglia, Mario; Ammassari-Teule, Martine.

In: Pharmacology, Biochemistry and Behavior, Vol. 36, No. 2, 1990, p. 389-392.

Research output: Contribution to journalArticle

Sansone, Mario ; Castellano, Claudio ; Battaglia, Mario ; Ammassari-Teule, Martine. / Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice. In: Pharmacology, Biochemistry and Behavior. 1990 ; Vol. 36, No. 2. pp. 389-392.
@article{87fe67de0119487c8399a9426d24b6f6,
title = "Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice",
abstract = "The nicotinic antagonist mecamylamine (2.5 and 5 mg/kg/IP) depressed both active (shuttle-box) and passive (step-through) avoidance learning in mice of the DBA/2 strain. The nootropic drug oxiracetam (50 and 100 mg/kg/IP) improved acquisition in the multitrial active avoidance test, but had no effect on one-trial passive avoidance learning. When the two drugs were combined, oxiracetam did not counteract mecamylamine-induced impairment of passive avoidance learning, even if it maintained a facilitating action on shuttle-box avoidance acquisition in mice receiving the nicotinic receptor blocker. Prevention of mecamylamine-induced shuttle-box avoidance depression by oxiracetam indicates that central nicotinic mechanisms are probably involved in the improving effects exerted by nootropic drugs on learning.",
keywords = "Avoidance learning, Mecamylamine, Mice, Oxiracetam",
author = "Mario Sansone and Claudio Castellano and Mario Battaglia and Martine Ammassari-Teule",
year = "1990",
doi = "10.1016/0091-3057(90)90420-M",
language = "English",
volume = "36",
pages = "389--392",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice

AU - Sansone, Mario

AU - Castellano, Claudio

AU - Battaglia, Mario

AU - Ammassari-Teule, Martine

PY - 1990

Y1 - 1990

N2 - The nicotinic antagonist mecamylamine (2.5 and 5 mg/kg/IP) depressed both active (shuttle-box) and passive (step-through) avoidance learning in mice of the DBA/2 strain. The nootropic drug oxiracetam (50 and 100 mg/kg/IP) improved acquisition in the multitrial active avoidance test, but had no effect on one-trial passive avoidance learning. When the two drugs were combined, oxiracetam did not counteract mecamylamine-induced impairment of passive avoidance learning, even if it maintained a facilitating action on shuttle-box avoidance acquisition in mice receiving the nicotinic receptor blocker. Prevention of mecamylamine-induced shuttle-box avoidance depression by oxiracetam indicates that central nicotinic mechanisms are probably involved in the improving effects exerted by nootropic drugs on learning.

AB - The nicotinic antagonist mecamylamine (2.5 and 5 mg/kg/IP) depressed both active (shuttle-box) and passive (step-through) avoidance learning in mice of the DBA/2 strain. The nootropic drug oxiracetam (50 and 100 mg/kg/IP) improved acquisition in the multitrial active avoidance test, but had no effect on one-trial passive avoidance learning. When the two drugs were combined, oxiracetam did not counteract mecamylamine-induced impairment of passive avoidance learning, even if it maintained a facilitating action on shuttle-box avoidance acquisition in mice receiving the nicotinic receptor blocker. Prevention of mecamylamine-induced shuttle-box avoidance depression by oxiracetam indicates that central nicotinic mechanisms are probably involved in the improving effects exerted by nootropic drugs on learning.

KW - Avoidance learning

KW - Mecamylamine

KW - Mice

KW - Oxiracetam

UR - http://www.scopus.com/inward/record.url?scp=0025299464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025299464&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(90)90420-M

DO - 10.1016/0091-3057(90)90420-M

M3 - Article

C2 - 2356212

AN - SCOPUS:0025299464

VL - 36

SP - 389

EP - 392

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 2

ER -