Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice

Mario Sansone, Claudio Castellano, Mario Battaglia, Martine Ammassari-Teule

Research output: Contribution to journalArticlepeer-review

Abstract

The nicotinic antagonist mecamylamine (2.5 and 5 mg/kg/IP) depressed both active (shuttle-box) and passive (step-through) avoidance learning in mice of the DBA/2 strain. The nootropic drug oxiracetam (50 and 100 mg/kg/IP) improved acquisition in the multitrial active avoidance test, but had no effect on one-trial passive avoidance learning. When the two drugs were combined, oxiracetam did not counteract mecamylamine-induced impairment of passive avoidance learning, even if it maintained a facilitating action on shuttle-box avoidance acquisition in mice receiving the nicotinic receptor blocker. Prevention of mecamylamine-induced shuttle-box avoidance depression by oxiracetam indicates that central nicotinic mechanisms are probably involved in the improving effects exerted by nootropic drugs on learning.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • Avoidance learning
  • Mecamylamine
  • Mice
  • Oxiracetam

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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