OXY-SCORE: A global index to improve evaluation of oxidative stress by combining pro-and antioxidant markers

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Our group recently proposed OXY-SCORE, a summary index of oxidative stress, computed by combining plasma free and total malondialdehyde (F-and T-MDA), glutathione in disulphide/reduced forms (GSSG/GSH), a-and g-tocopherol (TH), urine isoprostanes (iPF-III) levels, and plasma individual antioxidant capacity. Here, we describe the methods for the determination of the analytes and for the computation of the scores. We also report the results of two studies testing the performances of OXY-SCORE, and showing its value in assessing the oxidative status of cardiovascular patients and healthy subjects.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages197-213
Number of pages17
Volume594
ISBN (Print)9781607614104
DOIs
Publication statusPublished - 2010

Publication series

NameMethods in Molecular Biology
Volume594
ISSN (Print)10643745

Keywords

  • Coronary artery disease
  • Glutathione
  • Isoprostanes
  • Malondialdehyde
  • Oxidative stress
  • Vitamin E

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

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