Oxygen administration at birth in preterm infants: a retrospective analysis

Maria Pierro, Fabrizio Ciralli, Mariarosa Colnaghi, Mara Vanzati, Domenica Mercadante, Dario Consonni, Fabio Mosca

Research output: Contribution to journalArticle


Objective: The aim of the study was to retrospectively investigate the association between initial oxygen concentration in delivery room and short-term outcomes in preterm infants. Methods: Data from infants needing neonatal resuscitation, born at our department between January 2008 and December 2011, were analyzed. Patients were divided into three groups based on gestational age: between 32 and 36 weeks, between 31 and 28 weeks, and below 28 weeks. Results: The administration of each additional unit of oxygen up to 50% showed an association with a 5% increased need for mechanical ventilation (MV) in the neonatal intensive care unit in infants between 32 and 36 weeks [adjusted odds ratio 1.1, 95% confidence interval (CI) 1.04–1.1] and infants between 28 and 31 weeks (adjusted odds ratio 1.12, 95% CI 1.08–1.44). On the contrary, in infants below 28 weeks, increasing initial concentration of supplementary oxygen did not show any association with MV. Conclusions: Initial oxygen concentration seems to be associated with increased MV in the NICU. Our observations further stress the need for randomized controlled studies in order to obtain definitive recommendations for the optimal initial oxygen concentration during neonatal resuscitation of preterm infants.

Original languageEnglish
Pages (from-to)2675-2680
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number16
Publication statusPublished - 2016


  • Guidelines
  • mechanical ventilation
  • neonatal resuscitation
  • oxygen
  • preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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