Abstract
Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red cell, causing a decreased oxygen affinity of hemoglobin according to the classical Bohr effect. No release of 2,3 diphosphoglycerate which may be bound to the membrane is thus necessary to explain the effect of propranolol on the oxygen dissociation curve of blood.
| Original language | English |
|---|---|
| Pages (from-to) | 300-301 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 182 |
| Issue number | 4109 |
| Publication status | Published - 1973 |
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Cite this
Oxygen affinity and electrolyte distribution of human blood : changes induced by propranolol. / Agostoni, A.; Berfasconi, C.; Gerli, G. C.; Luzzana, M.; Rossi-Bernardi, L.
In: Science, Vol. 182, No. 4109, 1973, p. 300-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxygen affinity and electrolyte distribution of human blood
T2 - changes induced by propranolol
AU - Agostoni, A.
AU - Berfasconi, C.
AU - Gerli, G. C.
AU - Luzzana, M.
AU - Rossi-Bernardi, L.
PY - 1973
Y1 - 1973
N2 - Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red cell, causing a decreased oxygen affinity of hemoglobin according to the classical Bohr effect. No release of 2,3 diphosphoglycerate which may be bound to the membrane is thus necessary to explain the effect of propranolol on the oxygen dissociation curve of blood.
AB - Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red cell, causing a decreased oxygen affinity of hemoglobin according to the classical Bohr effect. No release of 2,3 diphosphoglycerate which may be bound to the membrane is thus necessary to explain the effect of propranolol on the oxygen dissociation curve of blood.
UR - http://www.scopus.com/inward/record.url?scp=0015817841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015817841&partnerID=8YFLogxK
M3 - Article
C2 - 4742739
AN - SCOPUS:0015817841
VL - 182
SP - 300
EP - 301
JO - Science
JF - Science
SN - 0036-8075
IS - 4109
ER -