Oxygen deteriorates arterial function in type 1 diabetes

Daniel Gordin, Luciano Bernardi, Milla Rosengård-Bärlund, Ville Petteri Mäkinen, Aino Soro-Paavonen, Carol Forsblom, Anna Sandelin, Per Henrik Groop

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Although oxygen is commonly used to treat various medical conditions, it has recently been shown to worsen vascular function (arterial stiffness) in healthy volunteers and even more in patients in whom vascular function might already be impaired. The effects of oxygen on arterial function in patients with type 1 diabetes (T1D) are unknown, although such patients display disturbed vascular function already at rest. Therefore, we tested whether short-term oxygen administration may alter the arterial function in patients with T1D. Methods: We estimated arterial stiffness by augmentation index (AIx) and the pulse wave velocity equivalent (SI-DVP) in 98 patients with T1D and 49 age- and sex-matched controls at baseline and during hyperoxia by obtaining continuous noninvasive finger pressure waveforms using a recently validated method. Results: AIx and SI-DVP increased in patients (P 

Original languageEnglish
Pages (from-to)349-357
Number of pages9
JournalActa Diabetologica
Volume53
Issue number3
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Augmentation index
  • Blood pressure
  • Hyperoxia
  • Oxygen
  • Pulse wave velocity
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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