TRASPORTO DELL'OSSIGENO NELL'UOMO ALLE ALTE QUOTE. I. PRINCIPI ED ANALISI DELLE OSSERVAZIONI SPERIMENTALI RIPORTATE NELLA LETTERATURA INTERNAZIONALE

Translated title of the contribution: Oxygen transport in man at high altitude

P. Ascenzi, G. Amiconi

Research output: Contribution to journalArticle

Abstract

The aim of this review is to furnish both a synthesis of principles and an analysis of experimental observations reported in the international literature and concerned with the problem of oxygen transport in man living at a high altitude. Attention is focused either on some relevant biochemical parameters changing the oxygen affinity for the hemoglobin (allosteric effectors), cooperation among the oxygen binding sites), or on haematocrit changes (polycythemia). The range of activity concerning such mechanisms is also examined. The experimental investigations carried out on alpinists are compared with the results obtained on the indigenous populations living at a high altitude. The analysis of all these data indicate that the mechanisms worked up by the organism contribute to maintain the partial pressure of oxygen into mitochondria (~ 1 mmHg) independent of the partial alveolar pressure.

Translated title of the contributionOxygen transport in man at high altitude
Original languageItalian
Pages (from-to)145-153
Number of pages9
JournalMedicina dello Sport
Volume32
Issue number3
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

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