Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

Ingemar Björkhem, Anita Lövgren-Sandblom, Valerio Leoni, Steve Meaney, Lovisa Brodin, Lisette Salveson, Kristian Winge, Sven Pålhagen, Per Svenningsson

Research output: Contribution to journalArticle

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Abstract

Oxysterols are important for cholesterol homeostasis in the brain and may be affected in neurodegenerative diseases. The levels of the brain-derived oxysterol 24S-hydroxycholesterol (24S-OH) have been reported to be markedly reduced in the circulation of patients with Parkinson's disease (PD) (Lee et al., Antioxid. Redox Signal. 11 (2009) 407-420). The finding is surprising in view of the fact that other neurodegenerative diseases are associated with relatively modest effects on the circulating levels of 24S-OH. We determined the plasma and cerebrospinal fluid (CSF) levels of 24S-OH and 27-hydroxycholesterol (27-OH) in patients with PD with different disease duration using a highly accurate method based on isotope dilution-mass spectrometry. All the patients had plasma levels of the different oxysterols within the normal range. When analyzing CSF, 10% of the PD patients were found to have levels of 24S-OH above the cut-off level and interestingly there was a significant correlation between levels of 24S-OH in CSF and duration of the disease (r= 0.40, P

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalNeuroscience Letters
Volume555
DOIs
Publication statusPublished - Oct 25 2013

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Parkinson Disease
Cerebrospinal Fluid
Neurodegenerative Diseases
Brain
Isotopes
Oxidation-Reduction
Mass Spectrometry
Reference Values
Homeostasis
Cholesterol
Oxysterols
24-hydroxycholesterol

Keywords

  • 24S-hydroxycholesterol
  • 27-Hydroxycholesterol
  • Biomarkers
  • Oxysterols

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Oxysterols and Parkinson's disease : Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. / Björkhem, Ingemar; Lövgren-Sandblom, Anita; Leoni, Valerio; Meaney, Steve; Brodin, Lovisa; Salveson, Lisette; Winge, Kristian; Pålhagen, Sven; Svenningsson, Per.

In: Neuroscience Letters, Vol. 555, 25.10.2013, p. 102-105.

Research output: Contribution to journalArticle

Björkhem, I, Lövgren-Sandblom, A, Leoni, V, Meaney, S, Brodin, L, Salveson, L, Winge, K, Pålhagen, S & Svenningsson, P 2013, 'Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease', Neuroscience Letters, vol. 555, pp. 102-105. https://doi.org/10.1016/j.neulet.2013.09.003
Björkhem, Ingemar ; Lövgren-Sandblom, Anita ; Leoni, Valerio ; Meaney, Steve ; Brodin, Lovisa ; Salveson, Lisette ; Winge, Kristian ; Pålhagen, Sven ; Svenningsson, Per. / Oxysterols and Parkinson's disease : Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. In: Neuroscience Letters. 2013 ; Vol. 555. pp. 102-105.
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