Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

Ingemar Björkhem, Anita Lövgren-Sandblom, Valerio Leoni, Steve Meaney, Lovisa Brodin, Lisette Salveson, Kristian Winge, Sven Pålhagen, Per Svenningsson

Research output: Contribution to journalArticle

Abstract

Oxysterols are important for cholesterol homeostasis in the brain and may be affected in neurodegenerative diseases. The levels of the brain-derived oxysterol 24S-hydroxycholesterol (24S-OH) have been reported to be markedly reduced in the circulation of patients with Parkinson's disease (PD) (Lee et al., Antioxid. Redox Signal. 11 (2009) 407-420). The finding is surprising in view of the fact that other neurodegenerative diseases are associated with relatively modest effects on the circulating levels of 24S-OH. We determined the plasma and cerebrospinal fluid (CSF) levels of 24S-OH and 27-hydroxycholesterol (27-OH) in patients with PD with different disease duration using a highly accurate method based on isotope dilution-mass spectrometry. All the patients had plasma levels of the different oxysterols within the normal range. When analyzing CSF, 10% of the PD patients were found to have levels of 24S-OH above the cut-off level and interestingly there was a significant correlation between levels of 24S-OH in CSF and duration of the disease (r= 0.40, P

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalNeuroscience Letters
Volume555
DOIs
Publication statusPublished - Oct 25 2013

    Fingerprint

Keywords

  • 24S-hydroxycholesterol
  • 27-Hydroxycholesterol
  • Biomarkers
  • Oxysterols

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Björkhem, I., Lövgren-Sandblom, A., Leoni, V., Meaney, S., Brodin, L., Salveson, L., Winge, K., Pålhagen, S., & Svenningsson, P. (2013). Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. Neuroscience Letters, 555, 102-105. https://doi.org/10.1016/j.neulet.2013.09.003