Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols

Laura Raccosta, Raffaella Fontana, Catia Traversari, Vincenzo Russo

Research output: Contribution to journalArticle

Abstract

By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses. We have recently identified a new tumor-supporting activity of oxysterols, which recruit neutrophils within tumor microenvironment by a chemokine (C-X-C motif) receptor 2 (CXCR2)-dependent, LXR-independent mechanism.

Original languageEnglish
Article numbere26469
JournalOncoImmunology
Volume2
Issue number11
DOIs
Publication statusPublished - 2013

Keywords

  • CXCR2
  • Immune evasion
  • Microenvironment
  • Oxysterols
  • Tumor-infiltrating neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Fingerprint Dive into the research topics of 'Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols'. Together they form a unique fingerprint.

  • Cite this