Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols

Laura Raccosta, Raffaella Fontana, Catia Traversari, Vincenzo Russo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses. We have recently identified a new tumor-supporting activity of oxysterols, which recruit neutrophils within tumor microenvironment by a chemokine (C-X-C motif) receptor 2 (CXCR2)-dependent, LXR-independent mechanism.

Original languageEnglish
Article numbere26469
JournalOncoImmunology
Volume2
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

CCR Receptors
Tumor Microenvironment
Neutrophils
Dendritic Cells
Neoplasms
Oxysterols
Liver X Receptors

Keywords

  • CXCR2
  • Immune evasion
  • Microenvironment
  • Oxysterols
  • Tumor-infiltrating neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment : The many facets of tumor-derived oxysterols. / Raccosta, Laura; Fontana, Raffaella; Traversari, Catia; Russo, Vincenzo.

In: OncoImmunology, Vol. 2, No. 11, e26469, 2013.

Research output: Contribution to journalArticle

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