Oxytocin inhibits proliferation of human breast cancer cell lines

P. Cassoni, A. Sapino, F. Negro, G. Bussolati

Research output: Contribution to journalArticle

Abstract

In this study we show that treatment of MDA-MB231 hormone-independent human breast cancer cells with oxytocin (OT) or with the OT analogue F314 induces significant growth inhibition together with a change in cell phenotype. In MCF7 and T47D human breast cancer cells, OT inhibits oestrogen-induced cell growth. In these same cells, OT administration significantly enhances the inhibitory effect of tamoxifen on cell proliferation. MDA-MB231, MCF7 and T47D cells all express mRNA specific for the OT receptor. These data suggest that it may be possible to inhibit breast cancer growth using OT and OT analogues.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalVirchows Archiv
Volume425
Issue number5
DOIs
Publication statusPublished - Dec 1994

Keywords

  • Breast cancer
  • Cell growth
  • Oxytocin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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