Oxytocin receptor within the breast: Biological function and distribution

Anna Sapino, Paola Cassoni, Anna Stella, Gianni Bussolati

Research output: Contribution to journalArticle

Abstract

In the present work first we reviewed and completed our previous experiments on the multiproliferative effect of oxytocin (OT) in breast cancer cell lines. In vitro, OT 10 nM and 100 nM inhibited cell proliferation of MDA-MB231 (human breast carcinoma) and TS/A (mouse mammary carcinoma) cell lines. In vivo, OT significantly reduced the growth of TS/A mammary tumors. Both effects are mediated by specific receptors (OTR) distributed on cell surface. Second, using immunohistochemistry and RT-PCR we detected OTR and OTR mRNA in normal and pathological breast tissue. There is no correlation among OTR presence in breast carcinomas and the age of patients, tumor stage, estrogen receptor positivity, oncogene expression and proliferation rate of the same tumor. On the contrary, progesterone and OTR expression are correlated. These data confirm our previous evidence of a role of OT and OTR in normal and neoplastic breast cells.

Original languageEnglish
Pages (from-to)2181-2186
Number of pages6
JournalAnticancer Research
Volume18
Issue number3 C
Publication statusPublished - May 1998

Keywords

  • Breast
  • Carcinomas
  • Oxytocin
  • Receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Oxytocin receptor within the breast: Biological function and distribution'. Together they form a unique fingerprint.

  • Cite this

    Sapino, A., Cassoni, P., Stella, A., & Bussolati, G. (1998). Oxytocin receptor within the breast: Biological function and distribution. Anticancer Research, 18(3 C), 2181-2186.