Ozonized gel against four Candida species: A pilot study and clinical perspectives

Vincenzina Monzillo, Fabiola Lallitto, Alba Russo, Claudio Poggio, Andrea Scribante, Carla Renata Arciola, Francesco Rocco Bertuccio, Marco Colombo

Research output: Contribution to journalArticlepeer-review


Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity. Oral Candida is the most common fungal infection in the mouth among denture wearers and people with weakened immune systems. In the case of generalized candidiasis or immunocompromised patients, systemic therapy is needed, while localized infections are treated with topic medications. However, many Candida strains are resistant to antifungal drugs. The aim of this preliminary analysis is to evaluate the antimycotic efficacy of a new ozonided oil (GeliO3), as a possible terapeutic alternative in local treatments of these infections, compared to chlorhexidine digluconate (Plak gel®). Chlorhexidine is a chemical synthesis disinfectant with a broad-spectrum antiseptic action, active against bacteria and fungi. Antimycotic activity was tested against the following four Candida species: C. albicans, C. parapsilosis, C. glabrata, C. tropicalis, through an agar diffusion method. No significant differences were found between the growth inhibition zone diameters of the ozonized gel and chlorhexidine. The results indicated that the ozonized gel may help to combat Candida infections. Moreover, useful applications could be used to counteract Candida colonization of endosseous implants.

Original languageEnglish
Article number1731
Issue number7
Publication statusPublished - Apr 1 2020


  • Antimycotic activity
  • Candida
  • Ozone
  • Ozonized olive oil

ASJC Scopus subject areas

  • Materials Science(all)


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