P-043. IGF-I measurement in post-operative evaluation of patients with tumours of the sellar region

M. L. Jaffrain-Rea, R. Baldelli, E. Ferretti, G. Minniti, V. Esposito, A. Santoro, A. Gulino, G. Tamburrano

Research output: Contribution to journalArticlepeer-review

Abstract

Hypopituitarism is frequent in patients operated for tumours of the seller region and impairement of GH secretion is usually the first marker of pituitary dysfunction. The sensitivity of IGF-I as a peripheral marker of GH secretion in the post-operative evaluation of pituitary function was studied in 35 patients after surgery for non-pituitary tumours (n = 20, including 11 craniopharyngiomas) and non-GH secreting pituitary macroadenomas (n = 15). Only four craniopharyngioma patients received post-operative radiation therapy. Plasma IGF-I was determined by VIA after acid-ethanol extraction. Results: Age-corrected IGF-I values were under the normal range in 15/20 patients with extra-pituitary tumours and in 8/15 patients with pituitary tumours, respectively. IGF-I values revere significantly correlated with tumour type (p = 45 years old (p45 years old.

Original languageEnglish
Pages (from-to)52
Number of pages1
JournalEndocrinology and Metabolism, Supplement
Volume4
Issue numberA
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Endocrinology

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