P-043. IGF-I measurement in post-operative evaluation of patients with tumours of the sellar region

M. L. Jaffrain-Rea; R. Baldelli; E. Ferretti; G. Minniti; V. Esposito; A. Santoro; A. Gulino; G. Tamburrano

P-043. IGF-I measurement in post-operative evaluation of patients with tumours of the sellar region

M. L. Jaffrain-Rea, R. Baldelli, E. Ferretti, G. Minniti, V. Esposito, A. Santoro, A. Gulino, G. Tamburrano

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Abstract

Hypopituitarism is frequent in patients operated for tumours of the seller region and impairement of GH secretion is usually the first marker of pituitary dysfunction. The sensitivity of IGF-I as a peripheral marker of GH secretion in the post-operative evaluation of pituitary function was studied in 35 patients after surgery for non-pituitary tumours (n = 20, including 11 craniopharyngiomas) and non-GH secreting pituitary macroadenomas (n = 15). Only four craniopharyngioma patients received post-operative radiation therapy. Plasma IGF-I was determined by VIA after acid-ethanol extraction. Results: Age-corrected IGF-I values were under the normal range in 15/20 patients with extra-pituitary tumours and in 8/15 patients with pituitary tumours, respectively. IGF-I values revere significantly correlated with tumour type (p = 45 years old (p45 years old.

Original language	English
Pages (from-to)	52
Number of pages	1
Journal	Endocrinology and Metabolism, Supplement
Volume	4
Issue number	A
Publication status	Published - 1997

ASJC Scopus subject areas

Endocrinology

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abstract = "Hypopituitarism is frequent in patients operated for tumours of the seller region and impairement of GH secretion is usually the first marker of pituitary dysfunction. The sensitivity of IGF-I as a peripheral marker of GH secretion in the post-operative evaluation of pituitary function was studied in 35 patients after surgery for non-pituitary tumours (n = 20, including 11 craniopharyngiomas) and non-GH secreting pituitary macroadenomas (n = 15). Only four craniopharyngioma patients received post-operative radiation therapy. Plasma IGF-I was determined by VIA after acid-ethanol extraction. Results: Age-corrected IGF-I values were under the normal range in 15/20 patients with extra-pituitary tumours and in 8/15 patients with pituitary tumours, respectively. IGF-I values revere significantly correlated with tumour type (p = 45 years old (p45 years old.",

author = "Jaffrain-Rea, {M. L.} and R. Baldelli and E. Ferretti and G. Minniti and V. Esposito and A. Santoro and A. Gulino and G. Tamburrano",

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T1 - P-043. IGF-I measurement in post-operative evaluation of patients with tumours of the sellar region

AU - Jaffrain-Rea, M. L.

AU - Baldelli, R.

AU - Ferretti, E.

AU - Minniti, G.

AU - Esposito, V.

AU - Santoro, A.

AU - Gulino, A.

AU - Tamburrano, G.

PY - 1997

Y1 - 1997

N2 - Hypopituitarism is frequent in patients operated for tumours of the seller region and impairement of GH secretion is usually the first marker of pituitary dysfunction. The sensitivity of IGF-I as a peripheral marker of GH secretion in the post-operative evaluation of pituitary function was studied in 35 patients after surgery for non-pituitary tumours (n = 20, including 11 craniopharyngiomas) and non-GH secreting pituitary macroadenomas (n = 15). Only four craniopharyngioma patients received post-operative radiation therapy. Plasma IGF-I was determined by VIA after acid-ethanol extraction. Results: Age-corrected IGF-I values were under the normal range in 15/20 patients with extra-pituitary tumours and in 8/15 patients with pituitary tumours, respectively. IGF-I values revere significantly correlated with tumour type (p = 45 years old (p45 years old.

AB - Hypopituitarism is frequent in patients operated for tumours of the seller region and impairement of GH secretion is usually the first marker of pituitary dysfunction. The sensitivity of IGF-I as a peripheral marker of GH secretion in the post-operative evaluation of pituitary function was studied in 35 patients after surgery for non-pituitary tumours (n = 20, including 11 craniopharyngiomas) and non-GH secreting pituitary macroadenomas (n = 15). Only four craniopharyngioma patients received post-operative radiation therapy. Plasma IGF-I was determined by VIA after acid-ethanol extraction. Results: Age-corrected IGF-I values were under the normal range in 15/20 patients with extra-pituitary tumours and in 8/15 patients with pituitary tumours, respectively. IGF-I values revere significantly correlated with tumour type (p = 45 years old (p45 years old.

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