Hypopituitarism is frequent in patients operated for tumours of the seller region and impairement of GH secretion is usually the first marker of pituitary dysfunction. The sensitivity of IGF-I as a peripheral marker of GH secretion in the post-operative evaluation of pituitary function was studied in 35 patients after surgery for non-pituitary tumours (n = 20, including 11 craniopharyngiomas) and non-GH secreting pituitary macroadenomas (n = 15). Only four craniopharyngioma patients received post-operative radiation therapy. Plasma IGF-I was determined by VIA after acid-ethanol extraction. Results: Age-corrected IGF-I values were under the normal range in 15/20 patients with extra-pituitary tumours and in 8/15 patients with pituitary tumours, respectively. IGF-I values revere significantly correlated with tumour type (p = 45 years old (p45 years old.
|Number of pages||1|
|Journal||Endocrinology and Metabolism, Supplement|
|Publication status||Published - 1997|
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