The preliminary results of an ongoing study of the effect of rhGH (0,8 IU/kg/w) on pituitary-thyroid axis in 45 GHD children are reported (C.A:11,5 ± 2,9 yr). Nineteen age-matched normal children served as controls. Other hormone deficiencies were excluded. T3, T4, FT3, FT4, T3/T4 ratio and TSH were assessed at 0-3-6-12 months' GH therapy. Data on TSH-curve after TRH(AUC) were available at baseline in all subjects and after 6-12 months of rhGH in 10 and 15 GHD children respectively. Neither differences in basal hormone levels between controls and GHD nor changes during rhGH were observed. However in GHD children the significantly lower pretreatment TSH-AUC values (501 ± 187 μ UI/ml/90'), compared to normal (691 ± 192), strikingly increased after 6 (893 ± 377) and 12 months' therapy (670 ± 200). rhGH did not affect the thyroid function in all but 2 GHD children, who developed hypothyroidism after 6 months. In spite of normal thyroid hormone levels, their TSH-AUC values were more than twice the average of controls as well as of euthyroid GH-treated children, while TSH basal level was normal in one of them and only slightly increased in the other. Our data point out the relevance of TSH-AUC after TRH in detecting mild thyroid axis changes in GHD as well as in its use as a sensitive index of the development of hypothyroidism induced by rhGH.
|Number of pages||1|
|Journal||Endocrinology and Metabolism, Supplement|
|Publication status||Published - 1997|
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