P-071. Effects of hexarelin alone or in combination with TRH on

G. H. Circulating, Tsh Levels, Normal Man, M. Arosio, G. Casati, O. Biella, E. Palmieri, S. Porretti, G. Faglia

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Abstract

Aim of the present paper is to verify whether a modification of the somatostatinergic tone is induced by the GH-releasing peptide, hexarelin (HEX). As somatostatin, apart from GH, is inhibitory on TSH secretion, we studied its effects on TRH-induced TSH secretion. Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different day: (a) TRH (200 μg/L i.v.) + placebo (P); (b) HEX (1 μg/Kg bw i.v.) + placebo (P) (c) combined TRH + HEX administration. Serum TSH and GH were measured by ultra-sensitive IFMAs. The responses to tests were evaluated as AUC calculated by trapezoidal method and were compared by a non-parametric method (Wilcoxon signed-rank). A significant increase in serum GH levels occurred after HEX administration, when given in combination either with P or with TRH (1217 × 470 vs 986±208 μg/min/L, p:NS), while no modifications of GH levels were seen after TRH + P. Serum TSH levels were unmodified by HEX injection. The increase elicited by TRH + HEX was similar to that elicited by TRH alone (1124±530 vs 1273±380 mU/min/L, p:NS). In conclusion: HEX administration did not modify basal and TRH-stimulated TSH secretion, thus suggesting that the GH-releasing effect of hexarelin is somatostatin-independent.

Original languageEnglish
Pages (from-to)63
Number of pages1
JournalEndocrinology and Metabolism, Supplement
Volume4
Issue numberA
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Endocrinology

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