P-071. Effects of hexarelin alone or in combination with TRH on

G. H. Circulating, Tsh Levels, Normal Man, M. Arosio, G. Casati, O. Biella, E. Palmieri, S. Porretti, G. Faglia

Research output: Contribution to journalArticlepeer-review


Aim of the present paper is to verify whether a modification of the somatostatinergic tone is induced by the GH-releasing peptide, hexarelin (HEX). As somatostatin, apart from GH, is inhibitory on TSH secretion, we studied its effects on TRH-induced TSH secretion. Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different day: (a) TRH (200 μg/L i.v.) + placebo (P); (b) HEX (1 μg/Kg bw i.v.) + placebo (P) (c) combined TRH + HEX administration. Serum TSH and GH were measured by ultra-sensitive IFMAs. The responses to tests were evaluated as AUC calculated by trapezoidal method and were compared by a non-parametric method (Wilcoxon signed-rank). A significant increase in serum GH levels occurred after HEX administration, when given in combination either with P or with TRH (1217 × 470 vs 986±208 μg/min/L, p:NS), while no modifications of GH levels were seen after TRH + P. Serum TSH levels were unmodified by HEX injection. The increase elicited by TRH + HEX was similar to that elicited by TRH alone (1124±530 vs 1273±380 mU/min/L, p:NS). In conclusion: HEX administration did not modify basal and TRH-stimulated TSH secretion, thus suggesting that the GH-releasing effect of hexarelin is somatostatin-independent.

Original languageEnglish
Pages (from-to)63
Number of pages1
JournalEndocrinology and Metabolism, Supplement
Issue numberA
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Endocrinology


Dive into the research topics of 'P-071. Effects of hexarelin alone or in combination with TRH on'. Together they form a unique fingerprint.

Cite this