Aims: To verify changes in clinical presentation and survival across five subsequent periods between 1975 and 1998. Methods: Six-hundred and one patients (pts) with squamous cell carcinoma (SCC) of the oral cavity, treated by a single Committee, are the subjects of this analysis. Results: The age distribution did not change, whereas the percentage of women increased from 9.3 to 22.3%. Presentation with T 1 was 4.1-times (95% CI: 2.0-8.2) more probable to occur in the last period compared with the initial period. The trend in nodal status was inconsistent. The probability of having distant metastases at presentation increased non-significantly, from 1.3 to 3.1%. Stage I was 3.9-fold more probable and radical therapy was 5.1-fold more probable in 1994-1998 than in the earliest period. After 5 years, 56% of pts had died from first SCC in 1975-1978 compared with 33% in 1989-1993 (last period not available). The HR adjusted for age, sex, area of residence, stage and therapy, of dying of first SCC in the most recent period compared with the initial one was 0.3 (95% CI: 0.2-0.4). Five-year overall observed survival improved from 32% in the first considered period to 51% in 1989-1993. The adjusted HR was 0.5 (95% CI: 0.4-0.6). Conclusion: There is evidence of a significant trend toward a better survival, independently from the diagnosis at earlier stages. It is possible that improvements in surgery, radiotherapy and medical oncology during the last 24 years and the systematic integrated approach within the framework of a multidisciplinary team, slightly contributed to this change.
|Issue number||SUPPL. 1|
|Publication status||Published - 2001|
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