P-093. non-parametric deconvolution provides an objective assessment of gh responses to gh-releasing stimuli in normals

A. Sartorio, S. Ferrero, G. De Nicolao, G. Pizzini, D. Liberati

Research output: Contribution to journalArticle

Abstract

The applicability of a new non-parametric deconvolution (DEC) to the analysis of GH 'response-to-stimuli' data was studied. Thirty healthy adults (I: n = 30) were tested with a single 1 μg/kg/bw GHRH bolus; group II (n = 6) was tested, on separate days, with 2 consecutive 1 μg/kg/bw GHRH (a) and hexarelin (b) boluses. A numerically efficient regularization-based non-parametric DEC algorithm incorporating non-negativity constraints was used to estimate the time profile of the instantaneous secretion rate (ISR) and its integral. Results: the analysis of the benchmark problem showed that the proposed method is capable of providing an accurate reconstruction of the ISR. The analysis of the data showed a clear rise in the ISR after the first bolus, with most of the response within 60′ from the stimulus. In group I, discarding the samples collected at 90-120′ only marginally affected the estimate of the cumulated 0′-60′ ISR (variation always

Original languageEnglish
Pages (from-to)71-72
Number of pages2
JournalEndocrinology and Metabolism, Supplement
Volume4
Issue numberA
Publication statusPublished - 1997

    Fingerprint

ASJC Scopus subject areas

  • Endocrinology

Cite this