Gli anticorpi p-ANCA ed ASCA nella diagnosi differenziale fra rettocolite ulcerosa e malattia di Crohn

Translated title of the contribution: p-ANCA and ASCA antibodies and the differential diagnosis between ulcerative colitis and Crohn's disease

Pierenrico Lecis, Bastianello Germanà, Nunziato Papa, Gianni Bertiato, Claudio Doglioni, Ermenegildo Galliani, Franco Costan Biedo

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-Saccaromyces cerevisiae antibodies (ASCA) seem to be associated with Crohn's disease (CD), while anti-neutrophil cytoplasm antibodies (p-ANCA) seem to be a recognised marker for ulcerative colitis (UC). Aim of our study was to determine whether the presence of ASCA and p-ANCA antibodies could differentiate CD from UC and IBD from aspecific chronic colitis (ACC). Methods: serum samples were obtained from 23 patients with CD and 32 with UC, and from 13 patients with aspecific chronic colitis. Diagnosis was established on clinical findings, endoscopy and histology. Determination of ASCA and p-ANCA antibodies was performed using indirect immunofluorescence technique and ELISA, respectively. Results: 20% CD patients against 50% UC patients expressed p-ANCA (p

Translated title of the contributionp-ANCA and ASCA antibodies and the differential diagnosis between ulcerative colitis and Crohn's disease
Original languageItalian
Pages (from-to)308-313
Number of pages6
JournalRecenti Progressi in Medicina
Volume93
Issue number5
Publication statusPublished - May 2002

ASJC Scopus subject areas

  • Medicine(all)

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