Gli anticorpi p-ANCA ed ASCA nella diagnosi differenziale fra rettocolite ulcerosa e malattia di Crohn

Pierenrico Lecis; Bastianello Germanà; Nunziato Papa; Gianni Bertiato; Claudio Doglioni; Ermenegildo Galliani; Franco Costan Biedo

Gli anticorpi p-ANCA ed ASCA nella diagnosi differenziale fra rettocolite ulcerosa e malattia di Crohn

Translated title of the contribution: p-ANCA and ASCA antibodies and the differential diagnosis between ulcerative colitis and Crohn's disease

Pierenrico Lecis, Bastianello Germanà, Nunziato Papa, Gianni Bertiato, Claudio Doglioni, Ermenegildo Galliani, Franco Costan Biedo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Anti-Saccaromyces cerevisiae antibodies (ASCA) seem to be associated with Crohn's disease (CD), while anti-neutrophil cytoplasm antibodies (p-ANCA) seem to be a recognised marker for ulcerative colitis (UC). Aim of our study was to determine whether the presence of ASCA and p-ANCA antibodies could differentiate CD from UC and IBD from aspecific chronic colitis (ACC). Methods: serum samples were obtained from 23 patients with CD and 32 with UC, and from 13 patients with aspecific chronic colitis. Diagnosis was established on clinical findings, endoscopy and histology. Determination of ASCA and p-ANCA antibodies was performed using indirect immunofluorescence technique and ELISA, respectively. Results: 20% CD patients against 50% UC patients expressed p-ANCA (p

Translated title of the contribution	p-ANCA and ASCA antibodies and the differential diagnosis between ulcerative colitis and Crohn's disease
Original language	Italian
Pages (from-to)	308-313
Number of pages	6
Journal	Recenti Progressi in Medicina
Volume	93
Issue number	5
Publication status	Published - May 2002

ASJC Scopus subject areas

Medicine(all)

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Gli anticorpi p-ANCA ed ASCA nella diagnosi differenziale fra rettocolite ulcerosa e malattia di Crohn. / Lecis, Pierenrico; Germanà, Bastianello; Papa, Nunziato; Bertiato, Gianni; Doglioni, Claudio; Galliani, Ermenegildo; Biedo, Franco Costan.

In: Recenti Progressi in Medicina, Vol. 93, No. 5, 05.2002, p. 308-313.

Research output: Contribution to journal › Article › peer-review

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abstract = "Anti-Saccaromyces cerevisiae antibodies (ASCA) seem to be associated with Crohn's disease (CD), while anti-neutrophil cytoplasm antibodies (p-ANCA) seem to be a recognised marker for ulcerative colitis (UC). Aim of our study was to determine whether the presence of ASCA and p-ANCA antibodies could differentiate CD from UC and IBD from aspecific chronic colitis (ACC). Methods: serum samples were obtained from 23 patients with CD and 32 with UC, and from 13 patients with aspecific chronic colitis. Diagnosis was established on clinical findings, endoscopy and histology. Determination of ASCA and p-ANCA antibodies was performed using indirect immunofluorescence technique and ELISA, respectively. Results: 20% CD patients against 50% UC patients expressed p-ANCA (p",

keywords = "ASCA, Crohn's disease, p-ANCA, Serological markers, Ulcerative colitis",

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AU - Lecis, Pierenrico

AU - Germanà, Bastianello

AU - Papa, Nunziato

AU - Bertiato, Gianni

AU - Doglioni, Claudio

AU - Galliani, Ermenegildo

AU - Biedo, Franco Costan

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