p-Chlorophenylalanine-induced muricidal aggression in male and female laboratory rats

L. Valzelli, S. Bernasconi, S. Garattini

Research output: Contribution to journalArticle

Abstract

p-Chlorophenylalanine (pCPA), a potent inhibitor of serotonin synthesis, specifically depletes brain serotonin in a dose-dependent manner. The resulting impairment of serotonergic inhibitory control of the brain is considered responsible for the consequent muricidal aggression that arises in pCPA-treated rats independent of their strain-dependent genetic predisposition and sex propensity to display this behavior. Judging from the data obtained, the minimal impairment of serotonergic inhibitory control required to induce consistent muricidal aggression in rats of both sexes of the strains considered, corresponds to a brain serotonin depletion of about 55-60%.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalNeuropsychobiology
Volume7
Issue number6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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