P-CREB expression in human gliomas: Potential use in the differential diagnosis between astrocytoma and oligodendroglioma

Valeria Barresi, Stefania Mondello, Giovanni Branca, Thangavelu Soundara Rajan, Enrica Vitarelli, Giovanni Tuccari

Research output: Contribution to journalArticle

Abstract

Phosphorylated cyclic-AMP responsive element binding protein (p-CREB) is a transcription factor that is involved in gliomagenesis. For this reason, it was recently proposed as a potential therapeutic target in gliomas; however, gliomas comprise tumors with different biomolecular profile, clinical behavior, and response to chemotherapy. In the present study, we aimed to investigate whether p-CREB expression varies in the 2 main types of gliomas, astrocytomas and oligodendrogliomas. Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of different histologic grades by immunohistochemistry and Western blot analysis. p53 overexpression and the Ki-67 labeling index were also assessed in all the tumors. p-CREB immunohistochemical expression was present in 100% of the astrocytic tumors, but in only 46% of oligodendrogliomas (P =.0033 for grade II; P =.0041 for grade III tumors). Absence of p-CREB immunohistochemical expression was significantly associated with 1p/19q codeletion (P

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalHuman Pathology
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • 1p/19q codeletion
  • Astrocytoma
  • Oligodendroglioma
  • p-CREB
  • p53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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