Abstract
Phosphorylated cyclic-AMP responsive element binding protein (p-CREB) is a transcription factor that is involved in gliomagenesis. For this reason, it was recently proposed as a potential therapeutic target in gliomas; however, gliomas comprise tumors with different biomolecular profile, clinical behavior, and response to chemotherapy. In the present study, we aimed to investigate whether p-CREB expression varies in the 2 main types of gliomas, astrocytomas and oligodendrogliomas. Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of different histologic grades by immunohistochemistry and Western blot analysis. p53 overexpression and the Ki-67 labeling index were also assessed in all the tumors. p-CREB immunohistochemical expression was present in 100% of the astrocytic tumors, but in only 46% of oligodendrogliomas (P =.0033 for grade II; P =.0041 for grade III tumors). Absence of p-CREB immunohistochemical expression was significantly associated with 1p/19q codeletion (P
| Original language | English |
|---|---|
| Pages (from-to) | 231-238 |
| Number of pages | 8 |
| Journal | Human Pathology |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2015 |
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Keywords
- 1p/19q codeletion
- Astrocytoma
- Oligodendroglioma
- p-CREB
- p53
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
Cite this
P-CREB expression in human gliomas : Potential use in the differential diagnosis between astrocytoma and oligodendroglioma. / Barresi, Valeria; Mondello, Stefania; Branca, Giovanni; Rajan, Thangavelu Soundara; Vitarelli, Enrica; Tuccari, Giovanni.
In: Human Pathology, Vol. 46, No. 2, 01.02.2015, p. 231-238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - P-CREB expression in human gliomas
T2 - Potential use in the differential diagnosis between astrocytoma and oligodendroglioma
AU - Barresi, Valeria
AU - Mondello, Stefania
AU - Branca, Giovanni
AU - Rajan, Thangavelu Soundara
AU - Vitarelli, Enrica
AU - Tuccari, Giovanni
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Phosphorylated cyclic-AMP responsive element binding protein (p-CREB) is a transcription factor that is involved in gliomagenesis. For this reason, it was recently proposed as a potential therapeutic target in gliomas; however, gliomas comprise tumors with different biomolecular profile, clinical behavior, and response to chemotherapy. In the present study, we aimed to investigate whether p-CREB expression varies in the 2 main types of gliomas, astrocytomas and oligodendrogliomas. Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of different histologic grades by immunohistochemistry and Western blot analysis. p53 overexpression and the Ki-67 labeling index were also assessed in all the tumors. p-CREB immunohistochemical expression was present in 100% of the astrocytic tumors, but in only 46% of oligodendrogliomas (P =.0033 for grade II; P =.0041 for grade III tumors). Absence of p-CREB immunohistochemical expression was significantly associated with 1p/19q codeletion (P
AB - Phosphorylated cyclic-AMP responsive element binding protein (p-CREB) is a transcription factor that is involved in gliomagenesis. For this reason, it was recently proposed as a potential therapeutic target in gliomas; however, gliomas comprise tumors with different biomolecular profile, clinical behavior, and response to chemotherapy. In the present study, we aimed to investigate whether p-CREB expression varies in the 2 main types of gliomas, astrocytomas and oligodendrogliomas. Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of different histologic grades by immunohistochemistry and Western blot analysis. p53 overexpression and the Ki-67 labeling index were also assessed in all the tumors. p-CREB immunohistochemical expression was present in 100% of the astrocytic tumors, but in only 46% of oligodendrogliomas (P =.0033 for grade II; P =.0041 for grade III tumors). Absence of p-CREB immunohistochemical expression was significantly associated with 1p/19q codeletion (P
KW - 1p/19q codeletion
KW - Astrocytoma
KW - Oligodendroglioma
KW - p-CREB
KW - p53
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U2 - 10.1016/j.humpath.2014.10.011
DO - 10.1016/j.humpath.2014.10.011
M3 - Article
VL - 46
SP - 231
EP - 238
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 2
ER -