Abstract
Phosphorylated cyclic-AMP responsive element binding protein (p-CREB) is a transcription factor that is involved in gliomagenesis. For this reason, it was recently proposed as a potential therapeutic target in gliomas; however, gliomas comprise tumors with different biomolecular profile, clinical behavior, and response to chemotherapy. In the present study, we aimed to investigate whether p-CREB expression varies in the 2 main types of gliomas, astrocytomas and oligodendrogliomas. Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of different histologic grades by immunohistochemistry and Western blot analysis. p53 overexpression and the Ki-67 labeling index were also assessed in all the tumors. p-CREB immunohistochemical expression was present in 100% of the astrocytic tumors, but in only 46% of oligodendrogliomas (P =.0033 for grade II; P =.0041 for grade III tumors). Absence of p-CREB immunohistochemical expression was significantly associated with 1p/19q codeletion (P
Original language | English |
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Pages (from-to) | 231-238 |
Number of pages | 8 |
Journal | Human Pathology |
Volume | 46 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1 2015 |
Keywords
- 1p/19q codeletion
- Astrocytoma
- Oligodendroglioma
- p-CREB
- p53
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)