P-seclctin and von Willebrand factor in bovine mesenteric lymphatics: An immunofluorescent study

A. Di Nucci, C. Marchetti, S. Serafini, F. Piovella

Research output: Contribution to journalArticlepeer-review

Abstract

P-selectin (PADGEM, GUP-140, CD62) is an integral membrane protein specific to alpha granules of platelets and Weibel-Palade bodies of blood vascular endothelial cells. The presence in lymphatic endothelial cells of numerous Weibel-Palade bodies and their positivity to immunocytochemical reaction for von Willebrand factor have previously been characterized and described. Because von Willebrand factor and P-selectin codistribute in Weibel-Palade bodies of blood vascular endothelial cells we investigated the presence of both P-selectin and von Willebrand factor in lymphatic endothelium. Lymphatic vessels expressed positive reaction to immunocytochemical assay thereby demonstrating the presence of P-selectin in the endothelium. Distribution and intensity of the reaction were similar to those observed in bovine blood vascular endothelium.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalLymphology
Volume29
Issue number1
Publication statusPublished - Mar 1996

ASJC Scopus subject areas

  • Immunology

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