TY - JOUR
T1 - P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis
AU - Scalabrini, Diego
AU - Galimberti, Daniela
AU - Fenoglio, Chiara
AU - Comi, Cristoforo
AU - De Riz, Milena
AU - Venturelli, Eliana
AU - Castelli, Luca
AU - Piccio, Laura
AU - Ronzoni, Marco
AU - Lovati, Carlo
AU - Mariani, Claudio
AU - Monaco, Francesco
AU - Bresolin, Nereo
AU - Scarpini, Elio
PY - 2005/11/18
Y1 - 2005/11/18
N2 - P-selectin glycoprotein ligand-1 (PSGL-1) is an important adhesion molecule involved in lymphocyte recruitment into the brain, which represents a crucial step in the pathogenesis of multiple sclerosis (MS). Three hundred twenty-one MS patients and 342 controls were genotyped for the presence of a polymorphism in the PSGL-1 gene, consisting of a variable number of tandem repeats (VNTR) originating three possible alleles: A, B and C, in order to test whether they influence the susceptibility and the course of the disease. No significant differences among allelic frequencies of A, B and C alleles in MS as compared with controls were observed. Stratifying patients according to the course of the disease, a significantly increased frequency of the shortest C allele in PP-MS was found (7.1%), either in comparison with controls (P = 0.011) or with all other MS patients, who had acute inflammatory attacks at onset and an initial RR form (P = 0.036). Besides, none of SP-MS patients was a carrier of the C allele and B carriers converted later from RR to SP course as compared with A/A subjects (after 15.8 rather than 8.8 years, P = 0.01). In conclusion, the C allele of the VNTR polymorphism in PSGL-1 is likely to be associated with PP-MS. As this allele has been demonstrated to have a very low efficiency in mediating lymphocyte binding to brain endothelium during attacks, its high frequency in PP-MS could be related to the absence of exacerbations in such patients.
AB - P-selectin glycoprotein ligand-1 (PSGL-1) is an important adhesion molecule involved in lymphocyte recruitment into the brain, which represents a crucial step in the pathogenesis of multiple sclerosis (MS). Three hundred twenty-one MS patients and 342 controls were genotyped for the presence of a polymorphism in the PSGL-1 gene, consisting of a variable number of tandem repeats (VNTR) originating three possible alleles: A, B and C, in order to test whether they influence the susceptibility and the course of the disease. No significant differences among allelic frequencies of A, B and C alleles in MS as compared with controls were observed. Stratifying patients according to the course of the disease, a significantly increased frequency of the shortest C allele in PP-MS was found (7.1%), either in comparison with controls (P = 0.011) or with all other MS patients, who had acute inflammatory attacks at onset and an initial RR form (P = 0.036). Besides, none of SP-MS patients was a carrier of the C allele and B carriers converted later from RR to SP course as compared with A/A subjects (after 15.8 rather than 8.8 years, P = 0.01). In conclusion, the C allele of the VNTR polymorphism in PSGL-1 is likely to be associated with PP-MS. As this allele has been demonstrated to have a very low efficiency in mediating lymphocyte binding to brain endothelium during attacks, its high frequency in PP-MS could be related to the absence of exacerbations in such patients.
KW - Adhesion molecules
KW - Genetics
KW - Multiple sclerosis
KW - P-selectin glycoprotein ligand-1
KW - Polymorphism
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U2 - 10.1016/j.neulet.2005.06.059
DO - 10.1016/j.neulet.2005.06.059
M3 - Article
C2 - 16039046
AN - SCOPUS:23944484234
VL - 388
SP - 149
EP - 152
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -