p14ARF is capable of promoting HIV-1 tat degradation

Barbara Gargano, Marianna Fiorillo, Stefano Amente, Barbara Majello, Luigi Lania

Research output: Contribution to journalArticlepeer-review


The p14ARF tumor suppressor functions as 'oncogenic checkpoint' that prevents unrestricted cellular proliferation in response to oncogenic signaling. Albeit, the major pathway through which ARF operates is the ARF-Mdm2-p53 axis, ARF directly binds to and inactivates transcription function of a number of DNA-bound activators. In the present study we show that p14 ARF inhibits transcription activation of HIV-1 LTR promoter activity by Tat protein. Tat protein is a RNA-bound transcriptional activator whose function is strictly required for HIV-1 replication. We determined that p14 ARF inhibits Tat transactivation of HIV-1 LTR by promoting Tat degradation via an ubiquitin-independent pathway.

Original languageEnglish
Pages (from-to)1433-1439
Number of pages7
JournalCell Cycle
Issue number10
Publication statusPublished - May 15 2008


  • Degradation
  • Gene expression
  • Inhibition
  • Oncosuppressor
  • p14
  • Tat
  • Ubiquitination

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)


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