Abstract
Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21(WAF1/CIP1) is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21(WAF1/CIP1) expression has been investigated immunohistochemically in a series of 191 patients with colorectal cancer of known p53 status. The purpose of the study was two-fold: to assess the relationship between p21(WAF1/CIP1) immunoreactivity and p53 alterations, and to evaluate the prognostic significance of p21(WAF1/CIP1) expression. In 96 carcinomas (51 per cent), p21(WAF1/CIP1) was expressed in over 10 per cent of tumour cells, whereas in 26, p21(WAF1/CIP1) was detected in under 10 per cent of neoplastic cells; 69 tumours lacked p21(WAF1/CIP1) expression. Immunoreactivity was more frequent in tumours of the right colon (p
| Original language | English |
|---|---|
| Pages (from-to) | 302-307 |
| Number of pages | 6 |
| Journal | Journal of Pathology |
| Volume | 187 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Colorectal carcinoma
- Immunohistochemistry
- p21(WAF1/CIP1)
- p53
- Prognosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
p21(WAF1/CIP1) expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. / Viale, Giuseppe; Pellegrini, Caterina; Mazzarol, Giovanni; Maisonneuve, Patrick; Silverman, Mark L.; Bosari, Silvano.
In: Journal of Pathology, Vol. 187, No. 3, 1999, p. 302-307.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - p21(WAF1/CIP1) expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations
AU - Viale, Giuseppe
AU - Pellegrini, Caterina
AU - Mazzarol, Giovanni
AU - Maisonneuve, Patrick
AU - Silverman, Mark L.
AU - Bosari, Silvano
PY - 1999
Y1 - 1999
N2 - Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21(WAF1/CIP1) is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21(WAF1/CIP1) expression has been investigated immunohistochemically in a series of 191 patients with colorectal cancer of known p53 status. The purpose of the study was two-fold: to assess the relationship between p21(WAF1/CIP1) immunoreactivity and p53 alterations, and to evaluate the prognostic significance of p21(WAF1/CIP1) expression. In 96 carcinomas (51 per cent), p21(WAF1/CIP1) was expressed in over 10 per cent of tumour cells, whereas in 26, p21(WAF1/CIP1) was detected in under 10 per cent of neoplastic cells; 69 tumours lacked p21(WAF1/CIP1) expression. Immunoreactivity was more frequent in tumours of the right colon (p
AB - Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21(WAF1/CIP1) is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21(WAF1/CIP1) expression has been investigated immunohistochemically in a series of 191 patients with colorectal cancer of known p53 status. The purpose of the study was two-fold: to assess the relationship between p21(WAF1/CIP1) immunoreactivity and p53 alterations, and to evaluate the prognostic significance of p21(WAF1/CIP1) expression. In 96 carcinomas (51 per cent), p21(WAF1/CIP1) was expressed in over 10 per cent of tumour cells, whereas in 26, p21(WAF1/CIP1) was detected in under 10 per cent of neoplastic cells; 69 tumours lacked p21(WAF1/CIP1) expression. Immunoreactivity was more frequent in tumours of the right colon (p
KW - Colorectal carcinoma
KW - Immunohistochemistry
KW - p21(WAF1/CIP1)
KW - p53
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=0032587519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032587519&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-9896(199902)187:3<302::AID-PATH243>3.0.CO;2-U
DO - 10.1002/(SICI)1096-9896(199902)187:3<302::AID-PATH243>3.0.CO;2-U
M3 - Article
C2 - 10398083
AN - SCOPUS:0032587519
VL - 187
SP - 302
EP - 307
JO - Journal of Pathology
JF - Journal of Pathology
SN - 0022-3417
IS - 3
ER -