P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia

Elena Adinolfi, Loredana Melchiorri, Simonetta Falzoni, Paola Chiozzi, Anna Morelli, Alessia Tieghi, Antonio Cuneo, Gianluigi Castoldi, Francesco Di Virgilio, Olavio R. Baricordi

Research output: Contribution to journalArticle

Abstract

Human leukocytes express a receptor for extracellular nucleotides, named P2X7R, that in lymphocytes can either mediate cell death or proliferation, depending on the level of activation. The authors have investigated P2X7R expression and function in 21 patients affected by B-cell chronic lymphocytic leukemia, 13 with an evolutive and 8 with an indolent variant of the disease. Resting cytoplasmic Ca++ concentration was significantly higher in lymphocytes from patients with the evolutive compared with indolent variant. Furthermore, in the former, P2X7R stimulation triggered a Ca++ influx significantly larger. Higher Ca++ influx correlated with an increased P2X7R expression in the lymphocytes from patients with the evolutive form. Finally, incubation in the presence of extracellular adenosine triphosphate decreased spontaneous proliferation of lymphocytes from patients affected with the evolutive variant but had no effects on lymphocytes from patients with the indolent form. These results suggest that expression and function of P2X7R may correlate with the severity of B-cell chronic lymphocytic leukemia.

Original languageEnglish
Pages (from-to)706-708
Number of pages3
JournalBlood
Volume99
Issue number2
DOIs
Publication statusPublished - Jan 15 2002

ASJC Scopus subject areas

  • Hematology

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    Adinolfi, E., Melchiorri, L., Falzoni, S., Chiozzi, P., Morelli, A., Tieghi, A., Cuneo, A., Castoldi, G., Di Virgilio, F., & Baricordi, O. R. (2002). P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia. Blood, 99(2), 706-708. https://doi.org/10.1182/blood.V99.2.706