P300 and EEG mapping in Down's syndrome

S. Medaglini, T. Locatelli, C. Fornara, M. Alberoni, M. Comola, M. Franceschi, N. Canal, G. Comi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cognitive impairment in Down's Syndrome (DS) has been described as being similar to Alzheimer type dementia (AD). Previous neurophysiological studies performed in DS patients showed a significant increase in latency of the auditory P300 and various EEG abnormalities (decrease in alpha and increase of slow frequencies). The aim of this study was to assess the presence of eventual EEG modifications and P300 abnormalities in 45 adult DS patients (16 males, 29 females; mean age 30.6 years). These subjects were subdivided into two groups on the basis of age: 33 subjects ranged from 20 to 35, while 12 subjects were aged between 36 and 56 years. All subjects underwent quantified EEG (qEEG) and auditory P300 mapping. We found a significant increase in delta power and a diffuse increase in theta power, mainly in DS patients with dementia than in patients without dementia. However the occurrence of qEEG changes in severely as well as in some mildly retarded DS patients makes it impossible to utilize the EEG for the diagnosis of dementia. Comparing the P300 of DS patients with normal controls we showed a statistically significant increase in latency for both early (N1, P2) and late (N2, P3) components. P300 latency was abnormal (> 2.5 sd) in 47% of the cases. The Z-score of P300 topographic distribution was abnormal in 37% of the patients. The latency increase and the amplitude decrease permitted differentiation of DS patients from controls but not young from old DS patients. Moreover the P300 latency did not distinguish demented from stable retarded patients. Similar to reports of dementia of different origin where amplitude attenuation of P300 wave is a feature of cognitive decline, we found that demented DS patients more frequently showed abnormal P300 amplitude maps when compared with stable retarded subjects.

Original languageEnglish
Pages (from-to)48-58
Number of pages11
JournalJournal of Psychophysiology
Volume11
Issue number1
Publication statusPublished - 1997

Fingerprint

Down Syndrome
Electroencephalography
Dementia
Alzheimer Disease

Keywords

  • Dementia
  • Down's syndrome
  • Electroencephalography
  • Event-related potentials
  • Evoked potentials
  • Mapping

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Medaglini, S., Locatelli, T., Fornara, C., Alberoni, M., Comola, M., Franceschi, M., ... Comi, G. (1997). P300 and EEG mapping in Down's syndrome. Journal of Psychophysiology, 11(1), 48-58.

P300 and EEG mapping in Down's syndrome. / Medaglini, S.; Locatelli, T.; Fornara, C.; Alberoni, M.; Comola, M.; Franceschi, M.; Canal, N.; Comi, G.

In: Journal of Psychophysiology, Vol. 11, No. 1, 1997, p. 48-58.

Research output: Contribution to journalArticle

Medaglini, S, Locatelli, T, Fornara, C, Alberoni, M, Comola, M, Franceschi, M, Canal, N & Comi, G 1997, 'P300 and EEG mapping in Down's syndrome', Journal of Psychophysiology, vol. 11, no. 1, pp. 48-58.
Medaglini S, Locatelli T, Fornara C, Alberoni M, Comola M, Franceschi M et al. P300 and EEG mapping in Down's syndrome. Journal of Psychophysiology. 1997;11(1):48-58.
Medaglini, S. ; Locatelli, T. ; Fornara, C. ; Alberoni, M. ; Comola, M. ; Franceschi, M. ; Canal, N. ; Comi, G. / P300 and EEG mapping in Down's syndrome. In: Journal of Psychophysiology. 1997 ; Vol. 11, No. 1. pp. 48-58.
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