P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region.

S. Staibano, L. Lo Muzio, G. Pannone, P. Somma, G. Farronato, R. Franco, F. Bambini, R. Serpico, G. De Rosa

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Abstract

Ultraviolet (UV) radiation plays a pivotal role in skin damage and photocarcinogenesis. The basic mechanism of phototoxicity lies in DNA damage, and involves mutation of tumor suppressor genes, oncogenes and genes directly involved in the control of the stability of genome, such as the mismatch repair (MR) genes. The goal of this study was to evaluate the role of p53 and hMSH2 in the UV-related carcinogenetic process. An immunohistochemical study for p53 and hMSH2 was performed in a series of 43 basal cell carcinomas (BCC) and 60 melanomas (MM) from photoexposed areas of head and neck region, comparing the findings with follow-up. A deregulated p53 expression characterized less differentiated, more aggressive BCC (BCC2) but not the well-differentiated ones (BCC1). The hMSH2 protein was present, though expressed at varying levels, in 18 out of 21 BCC1 cases and in 4 out of 22 BCC2. In the remaining 3 cases of BCC1 and 18 cases of BCC2, a complete absence of hMSH2 expression was found, correlating directly with the presence of recurrence and/or death of the disease in case of melanoma (p

Original languageEnglish
Pages (from-to)551-559
Number of pages9
JournalInternational Journal of Oncology
Volume19
Issue number3
Publication statusPublished - Sep 2001

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Basal Cell Carcinoma
Melanoma
Neck
Head
Phototoxic Dermatitis
DNA Mismatch Repair
Genomic Instability
Tumor Suppressor Genes
Oncogenes
Genes
DNA Damage
Radiation
Recurrence
Skin
Mutation
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region. / Staibano, S.; Lo Muzio, L.; Pannone, G.; Somma, P.; Farronato, G.; Franco, R.; Bambini, F.; Serpico, R.; De Rosa, G.

In: International Journal of Oncology, Vol. 19, No. 3, 09.2001, p. 551-559.

Research output: Contribution to journalArticle

Staibano, S, Lo Muzio, L, Pannone, G, Somma, P, Farronato, G, Franco, R, Bambini, F, Serpico, R & De Rosa, G 2001, 'P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region.', International Journal of Oncology, vol. 19, no. 3, pp. 551-559.
Staibano, S. ; Lo Muzio, L. ; Pannone, G. ; Somma, P. ; Farronato, G. ; Franco, R. ; Bambini, F. ; Serpico, R. ; De Rosa, G. / P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region. In: International Journal of Oncology. 2001 ; Vol. 19, No. 3. pp. 551-559.
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AU - Somma, P.

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AU - Franco, R.

AU - Bambini, F.

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