Abstract
Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
| Original language | English |
|---|---|
| Pages (from-to) | 33-35 |
| Number of pages | 3 |
| Journal | Acta Dermato-Venereologica, Supplement |
| Volume | 69 |
| Issue number | 146 |
| Publication status | Published - 1989 |
Keywords
- Oncogenes
- p53
- Psoriasis
ASJC Scopus subject areas
- Dermatology