P53 and oncogenes expression in psoriasis

G. Tadini, A. Cerri, L. Crosti, G. Cattoretti, E. Berti

Research output: Contribution to journalArticle

Abstract

Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalActa Dermato-Venereologica, Supplement
Volume69
Issue number146
Publication statusPublished - 1989

Keywords

  • Oncogenes
  • p53
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

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    Tadini, G., Cerri, A., Crosti, L., Cattoretti, G., & Berti, E. (1989). P53 and oncogenes expression in psoriasis. Acta Dermato-Venereologica, Supplement, 69(146), 33-35.