Abstract
Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
Original language | English |
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Pages (from-to) | 33-35 |
Number of pages | 3 |
Journal | Acta Dermato-Venereologica, Supplement |
Volume | 69 |
Issue number | 146 |
Publication status | Published - 1989 |
Keywords
- Oncogenes
- p53
- Psoriasis
ASJC Scopus subject areas
- Dermatology