Abstract
Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
| Original language | English |
|---|---|
| Pages (from-to) | 33-35 |
| Number of pages | 3 |
| Journal | Acta Dermato-Venereologica, Supplement |
| Volume | 69 |
| Issue number | 146 |
| Publication status | Published - 1989 |
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Keywords
- Oncogenes
- p53
- Psoriasis
ASJC Scopus subject areas
- Dermatology
Cite this
P53 and oncogenes expression in psoriasis. / Tadini, G.; Cerri, A.; Crosti, L.; Cattoretti, G.; Berti, E.
In: Acta Dermato-Venereologica, Supplement, Vol. 69, No. 146, 1989, p. 33-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - P53 and oncogenes expression in psoriasis
AU - Tadini, G.
AU - Cerri, A.
AU - Crosti, L.
AU - Cattoretti, G.
AU - Berti, E.
PY - 1989
Y1 - 1989
N2 - Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
AB - Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
KW - Oncogenes
KW - p53
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0024823407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024823407&partnerID=8YFLogxK
M3 - Article
C2 - 2532848
AN - SCOPUS:0024823407
VL - 69
SP - 33
EP - 35
JO - Acta Dermato-Venereologica, Supplement
JF - Acta Dermato-Venereologica, Supplement
SN - 0365-8341
IS - 146
ER -