p53 as the main traffic controller of the cell signaling network

Sinto Sebastian, Amalia Azzariti, Nicola Silvestris, Letizia Porcelli, Antonio Russo, Massimo Tommasino, Angelo Paradiso

Research output: Contribution to journalArticlepeer-review


Among different pathological conditions that affect human beings, cancer has received a great deal of attention primarily because it leads to significant morbidity and mortality. This is essetnially due to increasing worldwide incidence of this disease and the inability to discover the cause and molecular mechanisms by which normal human cells acquire the characteristics that define cancer cells. Since the discovery of p53 over a quarter of a century ago, it is now recognized that virtually all cell fate pathways of live cells and the decision to die are under the control of p53. Such extensive involvement indicates that p53 protein is acting as a major traffic controller in the cell signaling network. In cancer cells, many cell signaling pathways of normal human cells are rerouted towards immortalization and this is accomplished by the corruption of the main controllers of cell signaling pathways such as p53. This review highlights how p53 signaling activity is altered in cancer cells so that cells acquire the hallmarks of cancer including deregulated infinite self replicative potential.

Original languageEnglish
Pages (from-to)1172-1190
Number of pages19
JournalFrontiers in Bioscience
Issue number3
Publication statusPublished - Jun 1 2010


  • Apoptosis
  • Cancer
  • Cell cycle
  • Cell signaling
  • p53
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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